292537

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1538382..1538994 Replicon chromosome
Accession NZ_LS483421
Organism Streptococcus pyogenes strain NCTC10877

Toxin (Protein)


Gene name parE Uniprot ID A0A0H3C0F8
Locus tag DQN31_RS07800 Protein ID WP_009880846.1
Coordinates 1538659..1538994 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQN31_RS07795 Protein ID WP_002988079.1
Coordinates 1538382..1538669 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN31_RS07770 1533561..1534544 - 984 WP_014407847.1 tagatose-bisphosphate aldolase -
DQN31_RS07775 1534548..1535477 - 930 WP_111697165.1 tagatose-6-phosphate kinase -
DQN31_RS07780 1535523..1536038 - 516 WP_014407849.1 galactose-6-phosphate isomerase subunit LacB -
DQN31_RS07785 1536073..1536501 - 429 WP_014407850.1 galactose-6-phosphate isomerase subunit LacA -
DQN31_RS07790 1536948..1537721 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
DQN31_RS07795 1538382..1538669 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQN31_RS07800 1538659..1538994 + 336 WP_009880846.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQN31_RS09100 1539146..1539616 + 471 Protein_1420 integrase -
DQN31_RS09105 1539978..1540127 + 150 WP_011285175.1 integrase -
DQN31_RS07825 1540259..1540651 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQN31_RS07830 1540672..1541118 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQN31_RS07835 1541336..1541542 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQN31_RS07840 1541539..1542237 - 699 WP_014407851.1 hypothetical protein -
DQN31_RS07845 1542373..1543233 - 861 WP_011529009.1 DegV family protein -
DQN31_RS07850 1543330..1543848 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-107)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13204.95 Da        Isoelectric Point: 5.6809

>T292537 WP_009880846.1 NZ_LS483421:1538659-1538994 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFREVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292537 WP_002988079.1 NZ_LS483421:1538382-1538669 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3C0F8

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References