Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1530713..1531325 Replicon chromosome
Accession NZ_LS483420
Organism Streptococcus pyogenes strain NCTC13739

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DQN75_RS07780 Protein ID WP_111685196.1
Coordinates 1530990..1531325 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQN75_RS07775 Protein ID WP_002988079.1
Coordinates 1530713..1531000 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN75_RS07750 1525904..1526887 - 984 WP_012561005.1 tagatose-bisphosphate aldolase -
DQN75_RS07755 1526891..1527820 - 930 WP_012561006.1 tagatose-6-phosphate kinase -
DQN75_RS07760 1527866..1528381 - 516 WP_111685194.1 galactose-6-phosphate isomerase subunit LacB -
DQN75_RS07765 1528416..1528844 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
DQN75_RS07770 1529290..1530063 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
DQN75_RS07775 1530713..1531000 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQN75_RS07780 1530990..1531325 + 336 WP_111685196.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQN75_RS09070 1531452..1531946 + 495 WP_187416396.1 integrase -
DQN75_RS09075 1531909..1532442 + 534 WP_136112477.1 site-specific integrase -
DQN75_RS07795 1532574..1532966 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQN75_RS07800 1532987..1533433 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQN75_RS07805 1533651..1533857 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQN75_RS07810 1533854..1534552 - 699 WP_168688170.1 hypothetical protein -
DQN75_RS07815 1534688..1535548 - 861 WP_011529009.1 DegV family protein -
DQN75_RS07820 1535645..1536163 - 519 WP_111685198.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13147.91 Da        Isoelectric Point: 6.0913

>T292536 WP_111685196.1 NZ_LS483420:1530990-1531325 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHHHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292536 WP_002988079.1 NZ_LS483420:1530713-1531000 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References