Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 846835..847327 Replicon chromosome
Accession NZ_LS483418
Organism Streptococcus suis strain NCTC10234

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag DQM62_RS04265 Protein ID WP_011922404.1
Coordinates 846835..847092 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag DQM62_RS04270 Protein ID WP_012775104.1
Coordinates 847076..847327 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM62_RS04245 842469..843539 + 1071 WP_012775101.1 tyrosine recombinase XerS -
DQM62_RS04250 843609..845117 - 1509 WP_011922400.1 phosphomannomutase/phosphoglucomutase -
DQM62_RS04255 845193..846134 - 942 WP_012775102.1 sensor histidine kinase -
DQM62_RS04260 846131..846796 - 666 WP_012775103.1 response regulator transcription factor -
DQM62_RS04265 846835..847092 - 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQM62_RS04270 847076..847327 - 252 WP_012775104.1 hypothetical protein Antitoxin
DQM62_RS04275 847419..849389 - 1971 WP_012775105.1 FtsX-like permease family protein -
DQM62_RS04280 849390..850142 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
DQM62_RS04285 850278..851012 - 735 WP_011922410.1 ABC transporter permease -
DQM62_RS04290 851014..851760 - 747 WP_011922411.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T292532 WP_011922404.1 NZ_LS483418:c847092-846835 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT292532 WP_012775104.1 NZ_LS483418:c847327-847076 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References