Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1632894..1633562 Replicon chromosome
Accession NZ_LS483417
Organism Streptococcus pneumoniae strain NCTC11902

Toxin (Protein)


Gene name hicA Uniprot ID G0ICE6
Locus tag DQN54_RS08645 Protein ID WP_001132281.1
Coordinates 1633383..1633562 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag DQN54_RS08640 Protein ID WP_000961810.1
Coordinates 1632894..1633346 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN54_RS08615 1628784..1629527 - 744 WP_001188200.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
DQN54_RS08620 1629529..1630479 - 951 WP_000451127.1 50S ribosomal protein L11 methyltransferase -
DQN54_RS08625 1630617..1631045 - 429 WP_000418166.1 NUDIX hydrolase -
DQN54_RS08630 1631026..1632114 - 1089 WP_000719716.1 M50 family metallopeptidase -
DQN54_RS08635 1632133..1632603 - 471 WP_000257097.1 DUF3013 family protein -
DQN54_RS08640 1632894..1633346 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DQN54_RS08645 1633383..1633562 - 180 WP_001132281.1 type II toxin-antitoxin system HicA family toxin Toxin
DQN54_RS08650 1633699..1633878 - 180 WP_001809903.1 hypothetical protein -
DQN54_RS08660 1634043..1634282 - 240 WP_000818079.1 hypothetical protein -
DQN54_RS08670 1634552..1635823 + 1272 WP_001113209.1 replication-associated recombination protein A -
DQN54_RS08680 1636370..1637689 - 1320 WP_000502555.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6677.88 Da        Isoelectric Point: 11.0174

>T292530 WP_001132281.1 NZ_LS483417:c1633562-1633383 [Streptococcus pneumoniae]
IPMTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHGELNKYTERGIRKQAGL

Download         Length: 180 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT292530 WP_000961810.1 NZ_LS483417:c1633346-1632894 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0ICE6

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References