Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1144935..1145433 Replicon chromosome
Accession NZ_LS483417
Organism Streptococcus pneumoniae strain NCTC11902

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag DQN54_RS06060 Protein ID WP_001809704.1
Coordinates 1144935..1145189 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag DQN54_RS06065 Protein ID WP_000208080.1
Coordinates 1145191..1145433 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN54_RS06045 1140328..1142796 - 2469 WP_001152989.1 DNA gyrase subunit A -
DQN54_RS06050 1142990..1143976 + 987 WP_000204727.1 L-lactate dehydrogenase -
DQN54_RS06055 1144236..1144888 - 653 Protein_1134 potassium channel family protein -
DQN54_RS06060 1144935..1145189 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQN54_RS06065 1145191..1145433 - 243 WP_000208080.1 hypothetical protein Antitoxin
DQN54_RS06070 1145524..1146333 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
DQN54_RS06075 1146335..1147684 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
DQN54_RS06080 1147677..1148381 - 705 WP_000722076.1 response regulator transcription factor -
DQN54_RS06085 1148436..1149611 - 1176 WP_000886145.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T292529 WP_001809704.1 NZ_LS483417:c1145189-1144935 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT292529 WP_000208080.1 NZ_LS483417:c1145433-1145191 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References