292527

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1680733..1681345 Replicon chromosome
Accession NZ_LS483414
Organism Streptococcus pyogenes strain NCTC13736

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag DQN44_RS08735 Protein ID WP_002988077.1
Coordinates 1681010..1681345 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQN44_RS08730 Protein ID WP_002988079.1
Coordinates 1680733..1681020 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN44_RS08705 1675925..1676908 - 984 WP_111706034.1 tagatose-bisphosphate aldolase -
DQN44_RS08710 1676912..1677841 - 930 WP_030127320.1 tagatose-6-phosphate kinase -
DQN44_RS08715 1677887..1678402 - 516 WP_030127321.1 galactose-6-phosphate isomerase subunit LacB -
DQN44_RS08720 1678437..1678865 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
DQN44_RS08725 1679310..1680083 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
DQN44_RS08730 1680733..1681020 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQN44_RS08735 1681010..1681345 + 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQN44_RS09970 1681497..1681967 + 471 WP_030127322.1 site-specific integrase -
DQN44_RS09975 1681930..1682478 + 549 WP_180372439.1 site-specific integrase -
DQN44_RS08750 1682610..1683002 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQN44_RS08755 1683023..1683469 - 447 WP_011018228.1 50S ribosomal protein L13 -
DQN44_RS08760 1683687..1683893 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQN44_RS08765 1683890..1684588 - 699 WP_030127323.1 hypothetical protein -
DQN44_RS08770 1684724..1685584 - 861 WP_030127324.1 DegV family protein -
DQN44_RS08775 1685681..1686199 - 519 WP_011889154.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T292527 WP_002988077.1 NZ_LS483414:1681010-1681345 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292527 WP_002988079.1 NZ_LS483414:1680733-1681020 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References