Detailed information of TA system TA292526

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-HTH_XRE
• Location: 2195513..2196756
• Replicon: chromosome
• Accession: NZ_LS483413
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain NCTC7136

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: DQN40_RS11060
• Protein ID: WP_084916287.1
• Coordinates: 2195513..2196280 (-)
• Length: 256 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: DQN40_RS11065
• Protein ID: WP_084916288.1
• Coordinates: 2196280..2196756 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQN40_RS11035	2190791..2191891	+	1101	WP_000168218.1	DNA translocase FtsK	-
DQN40_RS11040	2191888..2192493	+	606	WP_084916284.1	hypothetical protein	-
DQN40_RS11045	2192692..2193297	+	606	WP_001040933.1	replication protein	-
DQN40_RS11050	2193290..2193538	+	249	WP_003055530.1	MerR family transcriptional regulator	-
DQN40_RS11055	2193627..2194892	+	1266	WP_084916286.1	site-specific integrase	-
DQN40_RS11060	2195513..2196280	-	768	WP_084916287.1	zeta toxin family protein	Toxin
DQN40_RS11065	2196280..2196756	-	477	WP_084916288.1	helix-turn-helix domain-containing protein	Antitoxin
DQN40_RS11070	2196866..2197078	-	213	WP_084916289.1	hypothetical protein	-
DQN40_RS11075	2197341..2198504	-	1164	WP_084916290.1	MFS transporter	-
DQN40_RS11080	2198491..2199267	-	777	WP_061600517.1	arginase family protein	-
DQN40_RS11085	2199264..2200442	-	1179	WP_159333946.1	radical SAM protein	-
DQN40_RS11090	2200533..2201396	-	864	Protein_2114	IS982 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2193627..2214275	20648
	-	flank	IS/Tn	-	-	2200782..2201396	614

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (26-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 256 a.a.
• Molecular weight: 29124.02 Da
• Isoelectric Point: 6.3943

>T292526 WP_084916287.1 NZ_LS483413:c2196280-2195513 [Streptococcus dysgalactiae subsp. equisimilis]
MKLEEFSQDNFEQASKRLVRSLTRGKTTSSQPKAILLGGQSGAGKTTIHRIKQREFQGNIIIIDGDSYRSFHPNYLGLQE
RYGKDSVDYTKVFAGQMVEYLVDELSKKGYHLLIEGTLRTTEVPKKTAQLLTTKGYQVSLAVIATKPELSYLSTLIRYEE
LHAIDPSQARATPKEHHDGIVEHLVDNLRELENDKIFNQIQIYQRDQSCIYDSQVDQISAAEVLQECLFGKWSKVEEEML
KLGQERLKELGEIDK

Nucleotide

• Length: 768 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18120.68 Da
• Isoelectric Point: 4.6272

>AT292526 WP_084916288.1 NZ_LS483413:c2196756-2196280 [Streptococcus dysgalactiae subsp. equisimilis]
MIGENIKTLRKAHNLTQPEFAKIVGISRNSLSRYENGTSRVSTELIDRICKKFNVSYIDIVGEEKMLTPVEDYQLTLKIE
VIKERGANILAQLYRFQDEQGIAFDDTSNPWVLMSDDLSDLINTKIYLVATFEDIERFNGYLDGIERMLEQATHLVVA

Nucleotide

• Length: 477 bp