Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1504585..1505120 Replicon chromosome
Accession NZ_LS483411
Organism Haemophilus influenzae strain NCTC11426

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DQN24_RS07375 Protein ID WP_050846954.1
Coordinates 1504585..1504848 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A112WVR2
Locus tag DQN24_RS07380 Protein ID WP_021035051.1
Coordinates 1504845..1505120 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN24_RS09010 1500272..1500445 - 174 WP_021035056.1 DUF5363 domain-containing protein -
DQN24_RS07360 1500442..1502412 - 1971 WP_111695638.1 tRNA(Met) cytidine acetyltransferase TmcA -
DQN24_RS07365 1502417..1502758 - 342 WP_050846956.1 SirB2 family protein -
DQN24_RS07370 1502820..1504490 - 1671 WP_044364316.1 energy-dependent translational throttle protein EttA -
DQN24_RS07375 1504585..1504848 - 264 WP_050846954.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
DQN24_RS07380 1504845..1505120 - 276 WP_021035051.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DQN24_RS07385 1505472..1506092 + 621 WP_111695639.1 zinc transporter binding subunit ZevA -
DQN24_RS07390 1506095..1507069 + 975 WP_111695640.1 zinc transporter permease subunit ZevB -
DQN24_RS07395 1507245..1507883 - 639 Protein_1392 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-87)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10298.03 Da        Isoelectric Point: 7.3198

>T292522 WP_050846954.1 NZ_LS483411:c1504848-1504585 [Haemophilus influenzae]
MISVSEEYKREFKKHIPLIINSPEYIEVMYCLLNSLPLPEKYKDHALTGNWKGWRDCHIKNDLVLIYKIVGDEIRLARLN
THPEIFG

Download         Length: 264 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10297.90 Da        Isoelectric Point: 5.6663

>AT292522 WP_021035051.1 NZ_LS483411:c1505120-1504845 [Haemophilus influenzae]
MAAVSFRVPDETKNIAFEVIKSYGLSPTQALNMFLAQIAKTKAIPVSLDYQTEQMPNSKTIMAMAELDNHNGREYKTLEE
FHQAMLSEMKL

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A112WVR2

References