Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 672814..673451 Replicon chromosome
Accession NZ_LS483411
Organism Haemophilus influenzae strain NCTC11426

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A121YHB9
Locus tag DQN24_RS03405 Protein ID WP_021035685.1
Coordinates 673047..673451 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag DQN24_RS03400 Protein ID WP_005656316.1
Coordinates 672814..673050 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN24_RS03375 668041..668781 - 741 WP_005662961.1 YebC/PmpR family DNA-binding transcriptional regulator -
DQN24_RS03380 668941..669417 - 477 WP_021035689.1 dihydroneopterin triphosphate diphosphatase -
DQN24_RS03385 669439..671205 - 1767 WP_111695398.1 aspartate--tRNA ligase -
DQN24_RS03390 671424..671942 + 519 WP_005688985.1 isoprenylcysteine carboxyl methyltransferase family protein -
DQN24_RS03395 671996..672721 + 726 WP_111695399.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
DQN24_RS03400 672814..673050 + 237 WP_005656316.1 antitoxin Antitoxin
DQN24_RS03405 673047..673451 + 405 WP_021035685.1 type II toxin-antitoxin system VapC family toxin Toxin
DQN24_RS03410 673518..673925 + 408 WP_005688980.1 lactoylglutathione lyase -
DQN24_RS03415 673999..674688 + 690 WP_021035684.1 ribonuclease T -
DQN24_RS03420 675002..676354 + 1353 WP_021035683.1 Na+/H+ antiporter family protein -
DQN24_RS03425 676387..676971 + 585 WP_021035682.1 primosomal replication protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15690.26 Da        Isoelectric Point: 8.9777

>T292521 WP_021035685.1 NZ_LS483411:673047-673451 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFSSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT292521 WP_005656316.1 NZ_LS483411:672814-673050 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A121YHB9

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References