Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 331553..332201 Replicon chromosome
Accession NZ_LS483411
Organism Haemophilus influenzae strain NCTC11426

Toxin (Protein)


Gene name toxT Uniprot ID A0A0Y7JUP0
Locus tag DQN24_RS01645 Protein ID WP_005694481.1
Coordinates 331553..331912 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag DQN24_RS01650 Protein ID WP_005650837.1
Coordinates 331905..332201 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN24_RS01640 328261..331283 + 3023 Protein_318 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
DQN24_RS01645 331553..331912 + 360 WP_005694481.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQN24_RS01650 331905..332201 + 297 WP_005650837.1 helix-turn-helix transcriptional regulator Antitoxin
DQN24_RS01655 332385..334301 + 1917 WP_111695306.1 ABC transporter ATP-binding protein -
DQN24_RS01660 334311..334847 + 537 WP_111695307.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
DQN24_RS01665 334863..335414 + 552 WP_042593999.1 Sua5/YciO/YrdC/YwlC family protein -
DQN24_RS01670 335418..336236 + 819 WP_111695308.1 shikimate dehydrogenase -
DQN24_RS01675 336233..336790 + 558 WP_111695309.1 DNA-3-methyladenine glycosylase I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(36-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-89)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 14321.67 Da        Isoelectric Point: 10.1408

>T292520 WP_005694481.1 NZ_LS483411:331553-331912 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVKLLSELGTSVGKPYVKHLDGEIWELRPIRDRILFARLM
DGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Download         Length: 360 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11092.94 Da        Isoelectric Point: 10.3139

>AT292520 WP_005650837.1 NZ_LS483411:331905-332201 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Y7JUP0

Antitoxin

Source ID Structure

References