Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 247683..248287 Replicon chromosome
Accession NZ_LS483411
Organism Haemophilus influenzae strain NCTC11426

Toxin (Protein)


Gene name relE Uniprot ID A0A2S9RBL9
Locus tag DQN24_RS01250 Protein ID WP_050948779.1
Coordinates 247979..248287 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q4QMK8
Locus tag DQN24_RS01245 Protein ID WP_005692346.1
Coordinates 247683..247979 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN24_RS01230 243449..244834 + 1386 WP_111695272.1 L-seryl-tRNA(Sec) selenium transferase -
DQN24_RS01235 244831..246690 + 1860 WP_111695273.1 selenocysteine-specific translation elongation factor -
DQN24_RS01240 246709..247563 + 855 WP_050951468.1 DUF3298 domain-containing protein -
DQN24_RS01245 247683..247979 + 297 WP_005692346.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DQN24_RS01250 247979..248287 + 309 WP_050948779.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
DQN24_RS01255 248345..251509 - 3165 WP_111695274.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
DQN24_RS01260 251810..253108 + 1299 WP_006995277.1 trigger factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-99)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11949.72 Da        Isoelectric Point: 7.8657

>T292519 WP_050948779.1 NZ_LS483411:247979-248287 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCHIQGDLVLIYQYV
IRDEFDELKFSRLNTHSQTALK

Download         Length: 309 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11003.27 Da        Isoelectric Point: 4.2845

>AT292519 WP_005692346.1 NZ_LS483411:247683-247979 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S9RBL9

Antitoxin

Source ID Structure
AlphaFold DB Q4QMK8

References