Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 183168..183646 Replicon chromosome
Accession NZ_LS483411
Organism Haemophilus influenzae strain NCTC11426

Toxin (Protein)


Gene name VapD Uniprot ID A0A112WLN3
Locus tag DQN24_RS00945 Protein ID WP_021034684.1
Coordinates 183168..183446 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0K9KX05
Locus tag DQN24_RS00950 Protein ID WP_012055040.1
Coordinates 183455..183646 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN24_RS00925 178356..180026 - 1671 WP_111695252.1 fructose-specific PTS transporter subunit EIIC -
DQN24_RS00930 180028..180969 - 942 WP_021034687.1 1-phosphofructokinase -
DQN24_RS00935 180971..182470 - 1500 WP_021034686.1 fused PTS fructose transporter subunit IIA/HPr protein -
DQN24_RS00940 182542..183072 - 531 WP_021034685.1 hypothetical protein -
DQN24_RS00945 183168..183446 - 279 WP_021034684.1 virulence-associated protein VapD Toxin
DQN24_RS00950 183455..183646 - 192 WP_012055040.1 DUF5397 family protein Antitoxin
DQN24_RS00955 183717..185015 - 1299 WP_021034683.1 hemolysin family protein -
DQN24_RS00960 185066..185590 - 525 WP_005669286.1 DUF1523 family protein -
DQN24_RS00965 185617..186399 - 783 WP_111695253.1 YchF/TatD family DNA exonuclease -
DQN24_RS00970 186435..187415 - 981 WP_021034681.1 DNA polymerase III subunit delta' -
DQN24_RS00975 187412..188044 - 633 WP_172453993.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10647.01 Da        Isoelectric Point: 4.9670

>T292518 WP_021034684.1 NZ_LS483411:c183446-183168 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAVLAKFGFVRTQGSLYTNTNEDMANLFQAMNELKQLAWISQSVRDIRAFRI
EQWSDFTDFIRS

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7018.97 Da        Isoelectric Point: 3.9930

>AT292518 WP_012055040.1 NZ_LS483411:c183646-183455 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDALVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A112WLN3

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9KX05

References