292516

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prpT-prpA/CC2985(antitoxin)
Location 2330577..2331117 Replicon chromosome
Accession NZ_LS483410
Organism Legionella pneumophila strain NCTC11404

Toxin (Protein)


Gene name PrpT Uniprot ID -
Locus tag DQN67_RS10655 Protein ID WP_014844324.1
Coordinates 2330821..2331117 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PrpA Uniprot ID -
Locus tag DQN67_RS10650 Protein ID WP_027224835.1
Coordinates 2330577..2330831 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN67_RS10630 2326481..2327656 - 1176 WP_027224832.1 ISL3 family transposase -
DQN67_RS10635 2327695..2328825 - 1131 WP_064319116.1 ISL3 family transposase -
DQN67_RS10640 2328980..2329558 + 579 WP_027224833.1 hypothetical protein -
DQN67_RS10645 2329663..2330229 + 567 WP_027224834.1 hypothetical protein -
DQN67_RS10650 2330577..2330831 + 255 WP_027224835.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
DQN67_RS10655 2330821..2331117 + 297 WP_014844324.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQN67_RS10665 2331578..2332592 - 1015 Protein_2057 transposase -
DQN67_RS10670 2332855..2333064 + 210 WP_010947832.1 cold-shock protein -
DQN67_RS10675 2333304..2334710 + 1407 WP_014844326.1 ATP-dependent RNA helicase DbpA -
DQN67_RS10680 2334867..2335778 + 912 WP_014844327.1 cation diffusion facilitator family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2325077..2337190 12113


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-94)

Antitoxin

Antitoxin ParD

(1-81)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11582.28 Da        Isoelectric Point: 7.2728

>T292516 WP_014844324.1 NZ_LS483410:2330821-2331117 [Legionella pneumophila]
MSNKTYRLYPKAVEDLESIYLYSTNEFGIKRTEDYILAIDLSFQRLADDPLIARKCDYIRPELRAFNVGSHIIFFKTTDY
GISVIRVLHQSMDFNRHL

Download         Length: 297 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9786.14 Da        Isoelectric Point: 9.9613

>AT292516 WP_027224835.1 NZ_LS483410:2330577-2330831 [Legionella pneumophila]
MTRTMTVDLGNELRNYVESLVRSGDYRSNSEVLRESLRLLREKQAESKLEQLRHLIDEGAASGKPETWDAHDFLKKMKKK
SHVK

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References