Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 70008..71545 | Replicon | chromosome |
Accession | NZ_LS483410 | ||
Organism | Legionella pneumophila strain NCTC11404 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | - |
Locus tag | DQN67_RS00335 | Protein ID | WP_032829405.1 |
Coordinates | 70008..71312 (-) | Length | 435 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | DQN67_RS00340 | Protein ID | WP_014840730.1 |
Coordinates | 71306..71545 (-) | Length | 80 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DQN67_RS00310 | 65570..66811 | + | 1242 | WP_061692303.1 | protein SdbC | - |
DQN67_RS00315 | 67114..67518 | - | 405 | WP_010945819.1 | MerR family transcriptional regulator | - |
DQN67_RS00320 | 67588..68340 | + | 753 | WP_106202069.1 | glutaredoxin family protein | - |
DQN67_RS00325 | 68530..69621 | + | 1092 | WP_027224672.1 | hypothetical protein | - |
DQN67_RS00330 | 69663..69938 | + | 276 | Protein_62 | integrase | - |
DQN67_RS00335 | 70008..71312 | - | 1305 | WP_032829405.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
DQN67_RS00340 | 71306..71545 | - | 240 | WP_014840730.1 | helix-turn-helix domain-containing protein | Antitoxin |
DQN67_RS00345 | 71912..72276 | + | 365 | Protein_65 | protein LvrA | - |
DQN67_RS00350 | 72386..72658 | + | 273 | WP_032829407.1 | hypothetical protein | - |
DQN67_RS00360 | 73353..74765 | - | 1413 | WP_027224675.1 | hypothetical protein | - |
DQN67_RS00365 | 74796..75404 | - | 609 | WP_027224676.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 435 a.a. Molecular weight: 49704.13 Da Isoelectric Point: 8.2954
>T292515 WP_032829405.1 NZ_LS483410:c71312-70008 [Legionella pneumophila]
MVMRKLYILMNNELVGELTQDNAGGLSFSYVADWISKPHSRPVSLSLPLVNQKFSGEVVYNFFDNLLPDNPQIRARIQAR
FQAKSSRPFDLLALIGSDCVGAIQIVERIPQTQRLSIESHVVSEAEIARTLRSYQTSPLGMDKEDDEFRISIAGAQEKTA
FLYYQNEWHKPFGPTPTTHIFKLPIGYLPHQGIDLSESCENEHLCLLLASKFGLDVAKSKILQFEDEKVLVVERFDRKWS
RDNRYILRLPQEDLCQALGYSPNLKYQSDGGPGIKEIMQLLNGSQQPQKDRDEFFRAQVVYWCLGAIDAHAKNFSISIQP
QGGYQLTPLYDIISAYPIVEQKQLSFKKLKMAMALYGKNIHYKIDGIQKRHFIETAKYVKYSKIKAAQIFEQVIDRIDSA
IDEVSRQLPNHFPEKIADPIFKGMRAFKERMIST
MVMRKLYILMNNELVGELTQDNAGGLSFSYVADWISKPHSRPVSLSLPLVNQKFSGEVVYNFFDNLLPDNPQIRARIQAR
FQAKSSRPFDLLALIGSDCVGAIQIVERIPQTQRLSIESHVVSEAEIARTLRSYQTSPLGMDKEDDEFRISIAGAQEKTA
FLYYQNEWHKPFGPTPTTHIFKLPIGYLPHQGIDLSESCENEHLCLLLASKFGLDVAKSKILQFEDEKVLVVERFDRKWS
RDNRYILRLPQEDLCQALGYSPNLKYQSDGGPGIKEIMQLLNGSQQPQKDRDEFFRAQVVYWCLGAIDAHAKNFSISIQP
QGGYQLTPLYDIISAYPIVEQKQLSFKKLKMAMALYGKNIHYKIDGIQKRHFIETAKYVKYSKIKAAQIFEQVIDRIDSA
IDEVSRQLPNHFPEKIADPIFKGMRAFKERMIST
Download Length: 1305 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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