Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/DinJ(antitoxin)
Location 1838762..1839368 Replicon chromosome
Accession NZ_LS483409
Organism Streptococcus gallolyticus strain NCTC13773

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DQN21_RS09170 Protein ID WP_077497399.1
Coordinates 1838762..1839094 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1S5WDU6
Locus tag DQN21_RS09175 Protein ID WP_009854657.1
Coordinates 1839084..1839368 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN21_RS09145 1834193..1834801 - 609 WP_009854651.1 TVP38/TMEM64 family protein -
DQN21_RS09150 1835049..1835351 - 303 WP_009854652.1 PepSY domain-containing protein -
DQN21_RS09155 1835594..1837099 - 1506 WP_174564820.1 HAMP domain-containing histidine kinase -
DQN21_RS09160 1837071..1837763 - 693 WP_009854654.1 response regulator transcription factor -
DQN21_RS09165 1837869..1838747 - 879 WP_077497397.1 DUF3114 domain-containing protein -
DQN21_RS09170 1838762..1839094 - 333 WP_077497399.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
DQN21_RS09175 1839084..1839368 - 285 WP_009854657.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DQN21_RS09180 1839642..1840160 + 519 WP_077497401.1 TetR/AcrR family transcriptional regulator -
DQN21_RS09185 1840274..1842043 + 1770 WP_009854659.1 oleate hydratase -
DQN21_RS09190 1842173..1843000 - 828 WP_077497403.1 class C sortase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-108)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(8-55)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12975.92 Da        Isoelectric Point: 8.6852

>T292514 WP_077497399.1 NZ_LS483409:c1839094-1838762 [Streptococcus gallolyticus]
MDYKKYKLIYSQRGIDTLDDIYHYIANEIGSTINAKKKIASIRKDLQRLEFFPEGGFDADEKFGKCLDPKYKTRGLTLSK
DYIALYNILENEVRIAYLLPTRSDYMDLFR

Download         Length: 333 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11125.47 Da        Isoelectric Point: 4.7049

>AT292514 WP_009854657.1 NZ_LS483409:c1839368-1839084 [Streptococcus gallolyticus]
MALAYDKSYNLRTYQKIYNQAEKVFKENNLNTAQALNLFLKNVAETGQLNLKTEEELKREKLFKNLQAEIQQSYAEFDEG
KFYTDEDLVERYGL

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1S5WDU6

References