Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1662519..1663099 Replicon chromosome
Accession NZ_LS483409
Organism Streptococcus gallolyticus strain NCTC13773

Toxin (Protein)


Gene name hicA Uniprot ID F5WVJ0
Locus tag DQN21_RS08380 Protein ID WP_009854536.1
Coordinates 1662911..1663099 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag DQN21_RS08375 Protein ID WP_077497294.1
Coordinates 1662519..1662899 (-) Length 127 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN21_RS08360 1657982..1658458 - 477 WP_014294902.1 shikimate kinase -
DQN21_RS08365 1658451..1659734 - 1284 WP_077497290.1 3-phosphoshikimate 1-carboxyvinyltransferase -
DQN21_RS08370 1659956..1661791 - 1836 WP_077497292.1 translation elongation factor 4 -
DQN21_RS08375 1662519..1662899 - 381 WP_077497294.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DQN21_RS08380 1662911..1663099 - 189 WP_009854536.1 type II toxin-antitoxin system HicA family toxin Toxin
DQN21_RS08385 1663195..1663860 - 666 WP_174564805.1 type II-A CRISPR-associated protein Csn2 -
DQN21_RS08390 1663847..1664191 - 345 WP_009854538.1 CRISPR-associated endonuclease Cas2 -
DQN21_RS08395 1664188..1665054 - 867 WP_077497298.1 type II CRISPR-associated endonuclease Cas1 -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 63 a.a.        Molecular weight: 6837.25 Da        Isoelectric Point: 10.8207

>T292513 WP_009854536.1 NZ_LS483409:c1663099-1662911 [Streptococcus gallolyticus]
VPLTGRELAKLAVLKGWKEVRVKGSHHQFKKDGVPYILTIPIHGNKVLGVGLEKKILKDIGL

Download         Length: 189 bp


Antitoxin


Download         Length: 127 a.a.        Molecular weight: 14165.04 Da        Isoelectric Point: 4.2627

>AT292513 WP_077497294.1 NZ_LS483409:c1662899-1662519 [Streptococcus gallolyticus]
MLKSYPAIFHKEDDGSFWVEFPGFGGGTEGDDVEEAMKNAREMLESSLAAYLDEGLELPKVVDMSELSVEDGFITLIQAD
PSPYLKSTKAIRKNVTVPEWLVRLADREHVNYSEVLTQALEKKLQL

Download         Length: 381 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1S5WDX8


Antitoxin

Source ID Structure

References