Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/YoeB-RelB
Location 1184525..1185041 Replicon chromosome
Accession NZ_LS483409
Organism Streptococcus gallolyticus strain NCTC13773

Toxin (Protein)


Gene name Txe Uniprot ID F5X0X3
Locus tag DQN21_RS06040 Protein ID WP_014620143.1
Coordinates 1184525..1184782 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID F5X0X4
Locus tag DQN21_RS06045 Protein ID WP_012961966.1
Coordinates 1184775..1185041 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN21_RS06015 1180010..1180618 + 609 WP_077496832.1 TipC family immunity protein -
DQN21_RS06020 1180801..1181649 - 849 WP_077496834.1 MurR/RpiR family transcriptional regulator -
DQN21_RS06025 1181819..1182802 + 984 WP_077496836.1 Gfo/Idh/MocA family oxidoreductase -
DQN21_RS06030 1182807..1183331 + 525 WP_009854177.1 heme-binding protein -
DQN21_RS06035 1183352..1184410 + 1059 WP_077496838.1 Gfo/Idh/MocA family oxidoreductase -
DQN21_RS06040 1184525..1184782 - 258 WP_014620143.1 Txe/YoeB family addiction module toxin Toxin
DQN21_RS06045 1184775..1185041 - 267 WP_012961966.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DQN21_RS06050 1185205..1185537 + 333 WP_009854181.1 putative DNA-binding protein -
DQN21_RS06055 1185608..1187173 + 1566 WP_061100435.1 signal recognition particle protein -
DQN21_RS06060 1187247..1188263 - 1017 WP_077496840.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10277.64 Da        Isoelectric Point: 8.7825

>T292512 WP_014620143.1 NZ_LS483409:c1184782-1184525 [Streptococcus gallolyticus]
MIKAWSDDAWNDYMYWYNQGNKATIKKINRLIKEIDRTPFTGIGKPEPLKHDLSGKWSRRITDEHRLIYSVDETTIYFYS
CKDHY

Download         Length: 258 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10365.60 Da        Isoelectric Point: 4.6290

>AT292512 WP_012961966.1 NZ_LS483409:c1185041-1184775 [Streptococcus gallolyticus]
MEAVAYSNFRQNLKHYMKQVNDDAEPLIVTSKNIDDTVVVLSKRDYDSMQETFRIMSNNYLMNKIKRGDEQFKAANFQTH
ELLEVDDD

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S5WCL9

Antitoxin

Source ID Structure
AlphaFold DB A0A1S5WCN9

References