Detailed information of TA system TA029251

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3185291..3185954
• Replicon: chromosome
• Accession: NC_020796
• Organism: Edwardsiella tarda C07-087

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: ETAC_RS14165
• Protein ID: WP_041692803.1
• Coordinates: 3185291..3185707 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D0ZDY6
• Locus tag: ETAC_RS14170
• Protein ID: WP_012849755.1
• Coordinates: 3185688..3185954 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETAC_RS14145	3181222..3182955	-	1734	WP_015462273.1	single-stranded-DNA-specific exonuclease RecJ	-
ETAC_RS14150	3182960..3183676	-	717	WP_015462274.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
ETAC_RS14155	3183704..3184603	-	900	WP_015462275.1	site-specific tyrosine recombinase XerD	-
ETAC_RS14160	3184754..3185266	+	513	WP_012849753.1	flavodoxin FldB	-
ETAC_RS14165	3185291..3185707	-	417	WP_041692803.1	protein YgfX	Toxin
ETAC_RS14170	3185688..3185954	-	267	WP_012849755.1	FAD assembly factor SdhE	Antitoxin
ETAC_RS14175	3186302..3187300	+	999	WP_015462277.1	tRNA-modifying protein YgfZ	-
ETAC_RS14180	3187343..3188167	-	825	WP_015462278.1	shikimate 5-dehydrogenase	-
ETAC_RS14185	3188326..3189198	-	873	WP_012849758.1	nucleoside-specific channel-forming protein Tsx	-
ETAC_RS14190	3189807..3190457	+	651	WP_015462279.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16243.06 Da
• Isoelectric Point: 11.6049

>T29251 WP_041692803.1 NC_020796:c3185707-3185291 [Edwardsiella piscicida C07-087]
VVLWRCNVHVSWRTQVMFLLGHGTLVLAILLAPWPENYSVFWLILLVAVIFECIRSQRRIARNRGELQLLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGAPCRRRLWLAADSMSREEWGQLRRTLLDAGDDRA

Nucleotide

• Length: 417 bp

>T29251 NC_020796:c3185707-3185291 [Edwardsiella piscicida C07-087]
GTGGTCCTTTGGCGCTGTAATGTTCACGTCTCCTGGCGTACCCAGGTGATGTTTCTGCTGGGGCACGGCACGCTGGTACT
GGCGATCCTGCTGGCGCCCTGGCCGGAAAACTACAGCGTATTCTGGCTGATTCTGCTGGTGGCGGTGATCTTTGAGTGTA
TCCGCAGCCAGCGCCGGATTGCGCGTAACCGCGGTGAGCTGCAGCTGCTGGCGCCGCAGGTGTGGCACTGGCAGCTGCGC
GAGTGGCGCCTGGCCCGACGTCCTTGGGTTAGCGATCTGGGGGCGCTGCTGATCCTGCAGAGTACCCATGGTGCGCCGTG
CCGCCGCCGTCTGTGGCTGGCGGCCGACAGCATGAGCCGCGAAGAGTGGGGGCAGCTGCGCCGCACGCTGCTCGATGCGG
GCGACGATCGCGCATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10318.90 Da
• Isoelectric Point: 5.6951

>AT29251 WP_012849755.1 NC_020796:c3185954-3185688 [Edwardsiella piscicida C07-087]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT29251 NC_020796:c3185954-3185688 [Edwardsiella piscicida C07-087]
ATGGATATCAATAATAAAGCGCGGGTTCACTGGGCGTGCCGCCGCGGAATGCGCGAGCTGGATATCGCCATCATGCCTTT
CTTTGAACATGAGTATGATGCGCTTAACGATGCCGATAAACAGACCTTTGTCCGCCTGCTGGCCTGTGACGATCCTGAGC
TATTTAAATGGCTGATGAACCAGGGTAAGCCGGATGACGCCGATCTGGCCCGCATGATTACGCTGATTCAGACGCGAAAT
AAAGAACGTGGTCCTTTGGCGCTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A034T2Q8