Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 259828..260437 Replicon chromosome
Accession NZ_LS483409
Organism Streptococcus gallolyticus strain NCTC13773

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DQN21_RS01505 Protein ID WP_077496054.1
Coordinates 259828..260157 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1S5WA73
Locus tag DQN21_RS01510 Protein ID WP_013642908.1
Coordinates 260147..260437 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN21_RS01475 254927..255580 + 654 WP_077496047.1 hypothetical protein -
DQN21_RS12675 255643..256515 + 873 WP_174564795.1 DnaD domain protein -
DQN21_RS01490 256881..257375 + 495 WP_077496049.1 hypothetical protein -
DQN21_RS01495 257690..258946 + 1257 WP_077496051.1 plasmid recombination protein -
DQN21_RS01500 259119..259649 + 531 WP_077496052.1 hypothetical protein -
DQN21_RS01505 259828..260157 - 330 WP_077496054.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQN21_RS01510 260147..260437 - 291 WP_013642908.1 hypothetical protein Antitoxin
DQN21_RS01515 260837..262060 - 1224 WP_077496056.1 site-specific integrase -
DQN21_RS01520 262115..262388 - 274 Protein_246 helix-turn-helix domain-containing protein -
DQN21_RS01525 262500..262832 - 333 WP_077496058.1 type II toxin-antitoxin system PemK/MazF family toxin -
DQN21_RS01530 262819..263124 - 306 WP_000162871.1 hypothetical protein -
DQN21_RS01535 263181..264236 - 1056 WP_077496059.1 CHAP domain-containing protein -
DQN21_RS01540 264245..264472 - 228 WP_077496061.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 220836..290248 69412


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12555.47 Da        Isoelectric Point: 8.3467

>T292508 WP_077496054.1 NZ_LS483409:c260157-259828 [Streptococcus gallolyticus]
MDYKISYNAGALEALVEIKEYIINNFKSETSAKKVVDNIMQKISALEIFPEVGFDADERFGKTLDKRHKTRGLTIGKDYI
ALYFVNDEKKEVVITHIVSTRSDYVKLFK

Download         Length: 330 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11015.58 Da        Isoelectric Point: 4.9477

>AT292508 WP_013642908.1 NZ_LS483409:c260437-260147 [Streptococcus gallolyticus]
MVVAEKNRAVTFQANKELVSEAKEVLNKKNLTLSHALRLFLQNVVVTNEIDLLNEEELEKEKLFRQLQGEIKQAIDDYEA
GVNTYSAEEVRKRLGL

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1S5WA73

References