Detailed information of TA system TA292507

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1267509..1268941
• Replicon: chromosome
• Accession: NZ_LS483408
• Organism: Streptococcus uberis strain NCTC4674

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: DQN33_RS06315
• Protein ID: WP_111673336.1
• Coordinates: 1268096..1268941 (+)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: DQN33_RS06310
• Protein ID: WP_041980508.1
• Coordinates: 1267509..1268099 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQN33_RS06310	1267509..1268099	+	591	WP_041980508.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
DQN33_RS06315	1268096..1268941	+	846	WP_111673336.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
DQN33_RS06320	1269003..1271804	-	2802	WP_111673337.1	CHAP domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-258)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32480.25 Da
• Isoelectric Point: 5.7560

>T292507 WP_111673336.1 NZ_LS483408:1268096-1268941 [Streptococcus uberis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQMTLSED
TVKQQLKEILADSEEGISFVIQSTTAIKESDDYGGYRATILCQLENIKQIIHLDIATGDIVTPQPITYDYKAIFNEDTFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLITVLISINSD

Nucleotide

• Length: 846 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23089.71 Da
• Isoelectric Point: 8.7432

>AT292507 WP_041980508.1 NZ_LS483408:1267509-1268099 [Streptococcus uberis]
MSKKEILLDFIEKNNGIITNKDCKALGIPTIYLTRLEKEGIIFRVEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTVPRGYRFNTPPANLNIHSVSKEYSELGITLVKTPMGNKVRVYDLERIICDFVIHREKIDTELFVKT
LQHYGNYSKKNLTKLYEYATKMNTLDKVKQTLEVLV

Nucleotide

• Length: 591 bp