Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 1246480..1247726 Replicon chromosome
Accession NZ_LS483408
Organism Streptococcus uberis strain NCTC4674

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag DQN33_RS06230 Protein ID WP_111673325.1
Coordinates 1246480..1247250 (-) Length 257 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag DQN33_RS06235 Protein ID WP_111673326.1
Coordinates 1247250..1247726 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN33_RS06210 1241496..1241855 - 360 WP_111673322.1 hypothetical protein -
DQN33_RS06220 1242201..1244219 - 2019 WP_111673324.1 ATP-dependent helicase -
DQN33_RS06225 1244223..1246466 - 2244 WP_044762374.1 AAA family ATPase -
DQN33_RS06230 1246480..1247250 - 771 WP_111673325.1 zeta toxin family protein Toxin
DQN33_RS06235 1247250..1247726 - 477 WP_111673326.1 helix-turn-helix domain-containing protein Antitoxin
DQN33_RS06240 1247796..1248086 - 291 WP_043037113.1 hypothetical protein -
DQN33_RS06245 1248136..1248525 - 390 WP_111673327.1 chemotaxis protein -
DQN33_RS06250 1248522..1248749 - 228 WP_023370180.1 hypothetical protein -
DQN33_RS06255 1248803..1249879 - 1077 WP_111673328.1 toprim domain-containing protein -
DQN33_RS06260 1249919..1250557 - 639 WP_111673329.1 peptidylprolyl isomerase -
DQN33_RS06265 1250820..1252148 - 1329 WP_111673330.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 257 a.a.        Molecular weight: 29428.44 Da        Isoelectric Point: 6.1768

>T292506 WP_111673325.1 NZ_LS483408:c1247250-1246480 [Streptococcus uberis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPEQPKAILLGGQSGAGKTTIHRIKQKEFQGDIIIIDGESYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTEVPRKTAQLLKSRGYKVSLAIIATMPELSYLSTLIRYEE
VYAVNPGQARATPKEHHDGIVEHLVDNLRELENDKLFDEIQIYQRNRWCVYDSEIDDGPAAEVLQEHLFGKWSKVEEEML
KVGRERLREFSVMKEN

Download         Length: 771 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18315.76 Da        Isoelectric Point: 4.3971

>AT292506 WP_111673326.1 NZ_LS483408:c1247726-1247250 [Streptococcus uberis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDETNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVV

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References