Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 103641..105224 Replicon chromosome
Accession NZ_LS483406
Organism Stenotrophomonas maltophilia strain NCTC10498

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag DQN96_RS00460 Protein ID WP_038646246.1
Coordinates 103641..104963 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag DQN96_RS00465 Protein ID WP_005407534.1
Coordinates 104967..105224 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN96_RS00440 99491..101122 - 1632 WP_162292022.1 TldD/PmbA family protein -
DQN96_RS00445 101461..102375 - 915 WP_012479096.1 IS110-like element ISStma7 family transposase -
DQN96_RS00455 103026..103640 + 615 WP_100438987.1 DUF938 domain-containing protein -
DQN96_RS00460 103641..104963 - 1323 WP_038646246.1 type II toxin-antitoxin system HipA family toxin Toxin
DQN96_RS00465 104967..105224 - 258 WP_005407534.1 helix-turn-helix transcriptional regulator Antitoxin
DQN96_RS00470 105386..109072 - 3687 WP_100438986.1 indolepyruvate ferredoxin oxidoreductase family protein -
DQN96_RS00475 109244..109879 + 636 WP_005407536.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 101461..102375 914


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-70)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49039.94 Da        Isoelectric Point: 6.9606

>T292502 WP_038646246.1 NZ_LS483406:c104963-103641 [Stenotrophomonas maltophilia]
MGTLQVWMNGVEVALWDDVRNGSSRLSYVSQWISSPQSRPLSLSLPLLPDGESHRGNVVNDYFDNLLPDNVAIRNRIRDR
FATRGSDTFDLLEAIGRDCVGAVQLLPPAHPPEDIQQITCEVLDEAGVATILRQVTTGNLPGAPSRDDAFRISIAGAQEK
TGLLLHAGKWCIPTGNTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMHLLSAFDIPVAETQMGRFNDQRALIVERFDRR
LSADRRWWLRLPQEDMCQVFGLPAARKYESDGGPGIVPIMDLLRQSEHPEDRAIFFKTQILFWMLAATDGHAKNFSVHLE
AGGRFRLTPVYDVLSVYPILGRGPNQLDPRNAQLAMAVHGKNRHRKLHLVRRRHWNETARACGVADGAEPWIKTLIAAVE
PAIQQVTRQLPDDFPSNVSEPIFNGLRAAAARLSSMAPEA

Download         Length: 1323 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9584.97 Da        Isoelectric Point: 11.8468

>AT292502 WP_005407534.1 NZ_LS483406:c105224-104967 [Stenotrophomonas maltophilia]
MDRPLHTVRTAQQLAPLMRAFRRQAGLSQAQLAERLGISRQAVGALERDPASASFERLMRIWAVLGLEVSLQQRSPQENT
SSLEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References