Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1584027..1584639 Replicon chromosome
Accession NZ_LS483399
Organism Streptococcus pyogenes strain NCTC8227

Toxin (Protein)


Gene name parE Uniprot ID A0A4Z2JY48
Locus tag DQM80_RS08210 Protein ID WP_002982731.1
Coordinates 1584304..1584639 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A5S4TJ53
Locus tag DQM80_RS08205 Protein ID WP_011055007.1
Coordinates 1584027..1584314 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM80_RS08180 1579215..1580198 - 984 WP_111702287.1 tagatose-bisphosphate aldolase -
DQM80_RS08185 1580202..1581135 - 934 Protein_1530 tagatose-6-phosphate kinase -
DQM80_RS08190 1581181..1581696 - 516 WP_030127321.1 galactose-6-phosphate isomerase subunit LacB -
DQM80_RS08195 1581731..1582159 - 429 WP_111702288.1 galactose-6-phosphate isomerase subunit LacA -
DQM80_RS08200 1582604..1583377 + 774 WP_111702289.1 DeoR/GlpR family DNA-binding transcription regulator -
DQM80_RS08205 1584027..1584314 + 288 WP_011055007.1 hypothetical protein Antitoxin
DQM80_RS08210 1584304..1584639 + 336 WP_002982731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQM80_RS09445 1584706..1585777 + 1072 Protein_1536 site-specific integrase -
DQM80_RS08235 1585909..1586301 - 393 WP_111702290.1 30S ribosomal protein S9 -
DQM80_RS08240 1586322..1586768 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQM80_RS08245 1586986..1587192 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQM80_RS08250 1587189..1587887 - 699 WP_063632128.1 hypothetical protein -
DQM80_RS08255 1588014..1588874 - 861 WP_002982687.1 DegV family protein -
DQM80_RS08260 1588971..1589489 - 519 WP_011055010.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13145.88 Da        Isoelectric Point: 5.2144

>T292500 WP_002982731.1 NZ_LS483399:1584304-1584639 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 5.2318

>AT292500 WP_011055007.1 NZ_LS483399:1584027-1584314 [Streptococcus pyogenes]
MTTVKKNRTVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z2JY48

Antitoxin

Source ID Structure
AlphaFold DB A0A5S4TJ53

References