Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3104933..3106532 Replicon chromosome
Accession NZ_LS483398
Organism Bordetella pertussis strain NCTC10910

Toxin (Protein)


Gene name hipA Uniprot ID Q7VVM6
Locus tag DQO07_RS15105 Protein ID WP_003816876.1
Coordinates 3104933..3106273 (-) Length 447 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag DQO07_RS15110 Protein ID WP_019247974.1
Coordinates 3106275..3106532 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQO07_RS15085 3100159..3100980 - 822 WP_014905903.1 IclR family transcriptional regulator -
DQO07_RS15090 3101395..3102473 - 1079 Protein_2930 tellurite resistance/C4-dicarboxylate transporter family protein -
DQO07_RS15095 3102705..3104135 - 1431 WP_019247976.1 MFS transporter -
DQO07_RS15100 3104148..3104837 + 690 WP_010931038.1 TetR/AcrR family transcriptional regulator -
DQO07_RS15105 3104933..3106273 - 1341 WP_003816876.1 type II toxin-antitoxin system HipA family toxin Toxin
DQO07_RS15110 3106275..3106532 - 258 WP_019247974.1 helix-turn-helix domain-containing protein Antitoxin
DQO07_RS15120 3106886..3108478 - 1593 WP_010931040.1 glutamine-hydrolyzing GMP synthase -
DQO07_RS15125 3108575..3110035 - 1461 WP_003812368.1 IMP dehydrogenase -
DQO07_RS15130 3110258..3110869 + 612 WP_010931041.1 DUF2239 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-70)


Sequences

Toxin        


Download         Length: 447 a.a.        Molecular weight: 49632.79 Da        Isoelectric Point: 7.4158

>T292499 WP_003816876.1 NZ_LS483398:c3106273-3104933 [Bordetella pertussis]
MGRRSHSRSLSIWTNGVRVGRWTVPARGEMELQYDVDWVRADVGRPLSLSLPFNLQNLPLKGERVANYFDNLLPDSDAIR
RRVAERFRTGSVDPFDLLKAIGRDCVGAVQILEDEEIPEGFDRIEGVPLSEEDIERHLIETVTPRAFAAGRDPDADFRIS
LAGAQEKTAFLWWGGQWLAPRGATSTSHIFKLPLGLVGGRRADFSTSVDNEWLCLKLLKAYGLDVAEASIATFGQQRVLV
VERFDRRVAPNGQWLMRLPQEDFCQVEGCSPLRKYENEGGPGLKALFATLRQSVNAAVDMRTLMAAQILFWLLRAPDGHA
KNFSIQLLPRGRFQLTRLYDVMSAYPVLGDGANQWSPFEIKLAMALIGKNRHYEMHGIQRRHFNSTAQKVGYGPTAEPII
EDLLARTPAIIAAVQADLPQDFSPRVADSVLGGLAQAAKSLGAMMP

Download         Length: 1341 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 8815.04 Da        Isoelectric Point: 7.1642

>AT292499 WP_019247974.1 NZ_LS483398:c3106532-3106275 [Bordetella pertussis]
MPPPSQPLLTTGQLGAVLQAARKAQGLTQSALASRIGLSQSRVSHLELNAHQLSVEQLLAWCAALGLELTIATRGSPAGS
SDADW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7VVM6

Antitoxin

Source ID Structure

References