Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 5390557..5391121 Replicon chromosome
Accession NZ_LS483395
Organism Achromobacter xylosoxidans strain NCTC10808

Toxin (Protein)


Gene name relE Uniprot ID A0A0D6IHV7
Locus tag DQO23_RS24655 Protein ID WP_020926667.1
Coordinates 5390557..5390838 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D6IHW1
Locus tag DQO23_RS24660 Protein ID WP_020926666.1
Coordinates 5390825..5391121 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQO23_RS24630 5385589..5386092 - 504 WP_006386642.1 flavin reductase family protein -
DQO23_RS24635 5386115..5387128 - 1014 WP_024070172.1 LLM class flavin-dependent oxidoreductase -
DQO23_RS24640 5387250..5388083 + 834 WP_024070173.1 IclR family transcriptional regulator -
DQO23_RS24645 5388319..5389374 + 1056 WP_054442897.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
DQO23_RS24650 5389371..5390507 + 1137 WP_024070175.1 tRNA guanosine(34) transglycosylase Tgt -
DQO23_RS24655 5390557..5390838 - 282 WP_020926667.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQO23_RS24660 5390825..5391121 - 297 WP_020926666.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DQO23_RS24665 5391493..5391837 + 345 WP_006386647.1 preprotein translocase subunit YajC -
DQO23_RS24670 5391953..5393833 + 1881 WP_006386648.1 protein translocase subunit SecD -
DQO23_RS24675 5393885..5394820 + 936 WP_006386649.1 protein translocase subunit SecF -
DQO23_RS24680 5394990..5395358 + 369 WP_006386650.1 type II toxin-antitoxin system RelE/ParE family toxin -
DQO23_RS24685 5395355..5395666 + 312 WP_006386651.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-52)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10262.77 Da        Isoelectric Point: 7.0080

>T292496 WP_020926667.1 NZ_LS483395:c5390838-5390557 [Achromobacter xylosoxidans]
VPAVEWSSAARADLLAIVDYISDDNPDAAQRLKDDIETKAAQLPARPALYRPGRIAGTREMVVRANYIIVYAADALAVRI
LRILHAAQQWPPQ

Download         Length: 282 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10717.24 Da        Isoelectric Point: 7.3208

>AT292496 WP_020926666.1 NZ_LS483395:c5391121-5390825 [Achromobacter xylosoxidans]
MPQTSMLHVRVDDKLKADATEKLAEFGLTISDAVRILLTRVAKEGGLPAGLTTDAQAHDAWFRAKVQEALADTGPAVPHQ
QVMDEAQALIDRKRRARS

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6IHV7

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6IHW1

References