Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1531214..1531826 Replicon chromosome
Accession NZ_LS483394
Organism Streptococcus pyogenes strain NCTC10880

Toxin (Protein)


Gene name parE Uniprot ID A0A4Z2JY48
Locus tag DQM37_RS07765 Protein ID WP_002982731.1
Coordinates 1531491..1531826 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQM37_RS07760 Protein ID WP_002988079.1
Coordinates 1531214..1531501 (+) Length 96 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM37_RS07735 1526403..1527386 - 984 WP_014407847.1 tagatose-bisphosphate aldolase -
DQM37_RS07740 1527390..1528319 - 930 WP_111694976.1 tagatose-6-phosphate kinase -
DQM37_RS07745 1528367..1528882 - 516 WP_014407849.1 galactose-6-phosphate isomerase subunit LacB -
DQM37_RS07750 1528917..1529345 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
DQM37_RS07755 1529791..1530564 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
DQM37_RS07760 1531214..1531501 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQM37_RS07765 1531491..1531826 + 336 WP_002982731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQM37_RS09145 1531978..1532448 + 471 Protein_1424 tyrosine-type recombinase/integrase family protein -
DQM37_RS07780 1532562..1532960 + 399 WP_197711562.1 tyrosine-type recombinase/integrase -
DQM37_RS07785 1533093..1533485 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQM37_RS07790 1533506..1533952 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQM37_RS07795 1534170..1534376 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQM37_RS07800 1534373..1535071 - 699 WP_172451603.1 hypothetical protein -
DQM37_RS07805 1535207..1536067 - 861 WP_011529009.1 DegV family protein -
DQM37_RS07810 1536164..1536682 - 519 WP_111694979.1 NYN domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-105)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 112 a.a.        Molecular weight: 13145.88 Da        Isoelectric Point: 5.2144

>T292491 WP_002982731.1 NZ_LS483394:1531491-1531826 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp


Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292491 WP_002988079.1 NZ_LS483394:1531214-1531501 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A4Z2JY48


Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References