Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1749253..1749787 Replicon chromosome
Accession NZ_LS483392
Organism Haemophilus influenzae strain NCTC11931

Toxin (Protein)


Gene name relE Uniprot ID A0A2X4DRE9
Locus tag DQM65_RS09050 Protein ID WP_041175309.1
Coordinates 1749253..1749432 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag DQM65_RS09055 Protein ID WP_111691834.1
Coordinates 1749512..1749787 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM65_RS10580 1744940..1745113 - 174 WP_172454834.1 DUF5363 domain-containing protein -
DQM65_RS09035 1745110..1747080 - 1971 WP_111691832.1 tRNA(Met) cytidine acetyltransferase TmcA -
DQM65_RS09040 1747085..1747426 - 342 WP_050846956.1 SirB2 family protein -
DQM65_RS09045 1747488..1749158 - 1671 WP_111691833.1 energy-dependent translational throttle protein EttA -
DQM65_RS09050 1749253..1749432 - 180 WP_041175309.1 type II toxin-antitoxin system YafQ family toxin Toxin
DQM65_RS09055 1749512..1749787 - 276 WP_111691834.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DQM65_RS09060 1750139..1750759 + 621 WP_050848568.1 zinc transporter binding subunit ZevA -
DQM65_RS09065 1750762..1751736 + 975 WP_111691835.1 zinc transporter permease subunit ZevB -
DQM65_RS10490 1751912..1752868 - 957 Protein_1728 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-58)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-81)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6913.05 Da        Isoelectric Point: 7.8827

>T292490 WP_041175309.1 NZ_LS483392:c1749432-1749253 [Haemophilus influenzae]
MYCLLNSLPLPEKYKDHALTGNWKGWRDCHIKNDLVLIYKIVGDEIRLARLNTHSEIFG

Download         Length: 180 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10275.81 Da        Isoelectric Point: 6.0646

>AT292490 WP_111691834.1 NZ_LS483392:c1749787-1749512 [Haemophilus influenzae]
MAAVSFRVPDETKNIAFEVIKSYGLSPTQALNMFLAQIAKTKAIPVSLDYQTEQMPNSKTIMAMAELDNHHGHEYKTLEE
FHQAMLSEMKS

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X4DRE9

Antitoxin

Source ID Structure

References