Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1240061..1240650 Replicon chromosome
Accession NZ_LS483392
Organism Haemophilus influenzae strain NCTC11931

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag DQM65_RS06280 Protein ID WP_111691546.1
Coordinates 1240061..1240309 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q9R3J9
Locus tag DQM65_RS06285 Protein ID WP_005668366.1
Coordinates 1240306..1240650 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM65_RS06250 1235436..1236068 + 633 WP_111691541.1 energy-coupling factor transporter transmembrane protein EcfT -
DQM65_RS06255 1236069..1236686 + 618 WP_111691542.1 energy-coupling factor ABC transporter ATP-binding protein -
DQM65_RS06265 1236909..1238099 - 1191 WP_111691543.1 aspartate/tyrosine/aromatic aminotransferase -
DQM65_RS06270 1238238..1239326 - 1089 WP_111691544.1 5-(carboxyamino)imidazole ribonucleotide synthase -
DQM65_RS06275 1239396..1239890 - 495 WP_111691545.1 5-(carboxyamino)imidazole ribonucleotide mutase -
DQM65_RS06280 1240061..1240309 + 249 WP_111691546.1 type II toxin-antitoxin system HicA family toxin Toxin
DQM65_RS06285 1240306..1240650 + 345 WP_005668366.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DQM65_RS06290 1240885..1243494 + 2610 WP_111691547.1 aminopeptidase N -
DQM65_RS06295 1243565..1244179 - 615 WP_111691548.1 riboflavin synthase -
DQM65_RS06300 1244223..1245617 + 1395 WP_006996443.1 sodium-coupled multidrug efflux MATE transporter HmrM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9426.96 Da        Isoelectric Point: 10.7140

>T292487 WP_111691546.1 NZ_LS483392:1240061-1240309 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELASLLAQQGYEKREMAGSRVRFYNRTLKHTILLHKPHPENYIKGSALKSVKESLKQVG
IL

Download         Length: 249 bp

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.08 Da        Isoelectric Point: 5.0113

>AT292487 WP_005668366.1 NZ_LS483392:1240306-1240650 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIKEKIFREKPSLR

Download         Length: 345 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806E3Y3

References