Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 751993..752630 Replicon chromosome
Accession NZ_LS483392
Organism Haemophilus influenzae strain NCTC11931

Toxin (Protein)


Gene name VapC1 Uniprot ID -
Locus tag DQM65_RS03905 Protein ID WP_101160683.1
Coordinates 752226..752630 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag DQM65_RS03900 Protein ID WP_005656316.1
Coordinates 751993..752229 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM65_RS03875 747370..748110 - 741 WP_005662961.1 YebC/PmpR family DNA-binding transcriptional regulator -
DQM65_RS03880 748123..748596 - 474 WP_172454808.1 dihydroneopterin triphosphate diphosphatase -
DQM65_RS03885 748618..750384 - 1767 WP_111691294.1 aspartate--tRNA ligase -
DQM65_RS03890 750603..751121 + 519 WP_005688985.1 isoprenylcysteine carboxyl methyltransferase family protein -
DQM65_RS03895 751175..751900 + 726 WP_044332436.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
DQM65_RS03900 751993..752229 + 237 WP_005656316.1 antitoxin Antitoxin
DQM65_RS03905 752226..752630 + 405 WP_101160683.1 type II toxin-antitoxin system VapC family toxin Toxin
DQM65_RS03910 752697..753104 + 408 WP_005628548.1 lactoylglutathione lyase -
DQM65_RS03915 753178..753867 + 690 WP_005686760.1 ribonuclease T -
DQM65_RS03920 754181..755533 + 1353 WP_111691295.1 Na+/H+ antiporter family protein -
DQM65_RS03925 755566..756150 + 585 WP_111691296.1 primosomal replication protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15551.12 Da        Isoelectric Point: 8.9778

>T292486 WP_101160683.1 NZ_LS483392:752226-752630 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVMSFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWASTLKKQGQPIGNNDLWIACHALSLNAVLITHNVKGFQRITDLQWQDWTK

Download         Length: 405 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT292486 WP_005656316.1 NZ_LS483392:751993-752229 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References