Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 392482..392953 Replicon chromosome
Accession NZ_LS483392
Organism Haemophilus influenzae strain NCTC11931

Toxin (Protein)


Gene name toxT Uniprot ID A0A806DTA9
Locus tag DQM65_RS02015 Protein ID WP_005654546.1
Coordinates 392482..392664 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag DQM65_RS02020 Protein ID WP_005650837.1
Coordinates 392657..392953 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM65_RS02000 388380..388619 - 240 WP_105893696.1 hypothetical protein -
DQM65_RS02010 389147..392212 + 3066 WP_111691100.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
DQM65_RS02015 392482..392664 + 183 WP_005654546.1 shikimate 5-dehydrogenase Toxin
DQM65_RS02020 392657..392953 + 297 WP_005650837.1 helix-turn-helix transcriptional regulator Antitoxin
DQM65_RS02025 393137..395053 + 1917 WP_111691101.1 ABC transporter ATP-binding protein -
DQM65_RS02030 395063..395599 + 537 WP_111691102.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
DQM65_RS02035 395615..396166 + 552 WP_111691103.1 Sua5/YciO/YrdC/YwlC family protein -
DQM65_RS02040 396170..396988 + 819 WP_111691104.1 shikimate dehydrogenase -
DQM65_RS02045 396985..397542 + 558 WP_111691105.1 DNA-3-methyladenine glycosylase I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(34-89)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7318.33 Da        Isoelectric Point: 6.3057

>T292484 WP_005654546.1 NZ_LS483392:392482-392664 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVIQTAQQRLSELKERLKNE

Download         Length: 183 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11092.94 Da        Isoelectric Point: 10.3139

>AT292484 WP_005650837.1 NZ_LS483392:392657-392953 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806DTA9

Antitoxin

Source ID Structure

References