Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 212007..212671 Replicon chromosome
Accession NZ_LS483392
Organism Haemophilus influenzae strain NCTC11931

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DQM65_RS01130 Protein ID WP_077583255.1
Coordinates 212270..212671 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DQM65_RS01125 Protein ID WP_111691011.1
Coordinates 212007..212270 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM65_RS01105 207689..208132 + 444 WP_111691981.1 TIGR03757 family integrating conjugative element protein -
DQM65_RS01110 208134..209054 + 921 WP_111691008.1 TIGR03756 family integrating conjugative element protein -
DQM65_RS01115 209065..211074 + 2010 WP_111691009.1 integrating conjugative element protein -
DQM65_RS01120 211141..211575 + 435 WP_111691010.1 hypothetical protein -
DQM65_RS10510 211690..211851 + 162 WP_172454799.1 hypothetical protein -
DQM65_RS01125 212007..212270 + 264 WP_111691011.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DQM65_RS01130 212270..212671 + 402 WP_077583255.1 type II toxin-antitoxin system VapC family toxin Toxin
DQM65_RS01135 212699..213034 + 336 WP_111691012.1 hypothetical protein -
DQM65_RS01140 213105..214628 - 1524 WP_111691013.1 conjugal transfer protein TraG N-terminal domain-containing protein -
DQM65_RS01145 214638..214940 - 303 WP_111691014.1 hypothetical protein -
DQM65_RS01150 214937..215332 - 396 WP_111691015.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 192542..228956 36414


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15130.57 Da        Isoelectric Point: 6.2184

>T292482 WP_077583255.1 NZ_LS483392:212270-212671 [Haemophilus influenzae]
MYMLDTNTVSDIVRKDPNVIRQLKSLSPESICISGITAAEIIYGLEKRQSTKLNQVMYPFLEVVTIYDWHYGVAQCYGKL
RAKMEKQGFVMGALDLMIAAHAVSENCTLVTSDNAFKMVPDLIIQNWREEHNI

Download         Length: 402 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10093.31 Da        Isoelectric Point: 4.5881

>AT292482 WP_111691011.1 NZ_LS483392:212007-212270 [Haemophilus influenzae]
MERVASLFKNGRSQAVRLPVDFEFNAKQIYIRKEANGDVVLSMRSQQQSSWDKMWSALDNLDTVDFLTPEERRQELSAQD
PFEGINL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References