Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 183628..184106 Replicon chromosome
Accession NZ_LS483392
Organism Haemophilus influenzae strain NCTC11931

Toxin (Protein)


Gene name VapD Uniprot ID A0A0K9L551
Locus tag DQM65_RS00955 Protein ID WP_050848517.1
Coordinates 183628..183906 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0K9KX05
Locus tag DQM65_RS00960 Protein ID WP_012055040.1
Coordinates 183915..184106 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM65_RS00935 178818..180488 - 1671 WP_111690982.1 fructose-specific PTS transporter subunit EIIC -
DQM65_RS00940 180490..181431 - 942 WP_111690983.1 1-phosphofructokinase -
DQM65_RS00945 181433..182932 - 1500 WP_111690984.1 fused PTS fructose transporter subunit IIA/HPr protein -
DQM65_RS00950 183002..183532 - 531 WP_172454796.1 hypothetical protein -
DQM65_RS00955 183628..183906 - 279 WP_050848517.1 virulence-associated protein VapD Toxin
DQM65_RS00960 183915..184106 - 192 WP_012055040.1 DUF5397 family protein Antitoxin
DQM65_RS00965 184177..185475 - 1299 WP_050948747.1 hemolysin family protein -
DQM65_RS00970 185526..186050 - 525 WP_005669286.1 DUF1523 family protein -
DQM65_RS00975 186077..186859 - 783 WP_111690986.1 YchF/TatD family DNA exonuclease -
DQM65_RS00980 186898..187878 - 981 WP_111690987.1 DNA polymerase III subunit delta' -
DQM65_RS00985 187875..188507 - 633 WP_172454847.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10604.98 Da        Isoelectric Point: 5.7408

>T292481 WP_050848517.1 NZ_LS483392:c183906-183628 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAVLAKFGFVRTQGSLYTNTNEDMANLFQAMNSLKQLAWISQSVRDIRAFRI
EQWSDFTDFIRS

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7018.97 Da        Isoelectric Point: 3.9930

>AT292481 WP_012055040.1 NZ_LS483392:c184106-183915 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDALVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9L551

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9KX05

References