Detailed information of TA system TA292480

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1630798..1631410
• Replicon: chromosome
• Accession: NZ_LS483391
• Organism: Streptococcus pyogenes strain NCTC8320

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q5X9X8
• Locus tag: DQN61_RS08645
• Protein ID: WP_011018227.1
• Coordinates: 1631075..1631410 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: DQN61_RS08640
• Protein ID: WP_011018226.1
• Coordinates: 1630798..1631085 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQN61_RS08615	1625976..1626959	-	984	WP_002982755.1	tagatose-bisphosphate aldolase	-
DQN61_RS08620	1626963..1627892	-	930	WP_002982751.1	tagatose-6-phosphate kinase	-
DQN61_RS08625	1627940..1628455	-	516	WP_002982748.1	galactose-6-phosphate isomerase subunit LacB	-
DQN61_RS08630	1628490..1628918	-	429	WP_002982747.1	galactose-6-phosphate isomerase subunit LacA	-
DQN61_RS08635	1629364..1630137	+	774	WP_002982738.1	DeoR/GlpR family DNA-binding transcription regulator	-
DQN61_RS08640	1630798..1631085	+	288	WP_011018226.1	hypothetical protein	Antitoxin
DQN61_RS08645	1631075..1631410	+	336	WP_011018227.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DQN61_RS09855	1631562..1632032	+	471	WP_030127322.1	site-specific integrase	-
DQN61_RS09860	1631995..1632543	+	549	WP_179854859.1	site-specific integrase	-
DQN61_RS08660	1632675..1633067	-	393	WP_002982716.1	30S ribosomal protein S9	-
DQN61_RS08665	1633088..1633534	-	447	WP_011018228.1	50S ribosomal protein L13	-
DQN61_RS08670	1633752..1633958	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
DQN61_RS08675	1633955..1634653	-	699	WP_172454633.1	hypothetical protein	-
DQN61_RS08680	1634789..1635649	-	861	WP_002982687.1	DegV family protein	-
DQN61_RS08685	1635746..1636264	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13171.97 Da
• Isoelectric Point: 5.2144

>T292480 WP_011018227.1 NZ_LS483391:1631075-1631410 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T292480 NZ_LS483391:1631075-1631410 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10950.56 Da
• Isoelectric Point: 5.2318

>AT292480 WP_011018226.1 NZ_LS483391:1630798-1631085 [Streptococcus pyogenes]
MTTVKKNRSVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT292480 NZ_LS483391:1630798-1631085 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGATCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A7Z2QKE7