Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1106231..1106729 Replicon chromosome
Accession NZ_LS483390
Organism Streptococcus pneumoniae strain NCTC13276

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag DQM93_RS05750 Protein ID WP_001809704.1
Coordinates 1106231..1106485 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag DQM93_RS05755 Protein ID WP_000208080.1
Coordinates 1106487..1106729 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM93_RS05745 1104285..1106156 - 1872 WP_000150986.1 Eco57I restriction-modification methylase domain-containing protein -
DQM93_RS05750 1106231..1106485 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQM93_RS05755 1106487..1106729 - 243 WP_000208080.1 hypothetical protein Antitoxin
DQM93_RS05760 1106820..1107629 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
DQM93_RS05765 1107631..1108980 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
DQM93_RS05770 1108973..1109677 - 705 WP_000722076.1 response regulator transcription factor -
DQM93_RS05775 1109732..1110907 - 1176 WP_000886145.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T292477 WP_001809704.1 NZ_LS483390:c1106485-1106231 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT292477 WP_000208080.1 NZ_LS483390:c1106729-1106487 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References