292475

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1654534..1655146 Replicon chromosome
Accession NZ_LS483389
Organism Streptococcus pyogenes strain NCTC10879

Toxin (Protein)


Gene name parE Uniprot ID A0A4Z2JY48
Locus tag DQM81_RS08585 Protein ID WP_002982731.1
Coordinates 1654811..1655146 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQM81_RS08580 Protein ID WP_002988079.1
Coordinates 1654534..1654821 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM81_RS08555 1649726..1650709 - 984 WP_020905487.1 tagatose-bisphosphate aldolase -
DQM81_RS08560 1650713..1651642 - 930 WP_020905488.1 tagatose-6-phosphate kinase -
DQM81_RS08565 1651688..1652203 - 516 WP_020905489.1 galactose-6-phosphate isomerase subunit LacB -
DQM81_RS08570 1652238..1652666 - 429 WP_053308614.1 galactose-6-phosphate isomerase subunit LacA -
DQM81_RS08575 1653111..1653884 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
DQM81_RS08580 1654534..1654821 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQM81_RS08585 1654811..1655146 + 336 WP_002982731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQM81_RS09955 1655298..1655768 + 471 Protein_1598 integrase -
DQM81_RS08600 1655882..1656232 + 351 WP_111679863.1 tyrosine-type recombinase/integrase -
DQM81_RS08605 1656400..1656792 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQM81_RS08610 1656813..1657259 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQM81_RS08615 1657477..1657683 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQM81_RS08620 1657680..1658378 - 699 WP_161237464.1 hypothetical protein -
DQM81_RS08625 1658514..1659374 - 861 WP_002982687.1 DegV family protein -
DQM81_RS08630 1659471..1659989 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13145.88 Da        Isoelectric Point: 5.2144

>T292475 WP_002982731.1 NZ_LS483389:1654811-1655146 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292475 WP_002988079.1 NZ_LS483389:1654534-1654821 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z2JY48

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References