Detailed information of TA system TA292474

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1240361..1241817
• Replicon: chromosome
• Accession: NZ_LS483387
• Organism: Streptococcus agalactiae strain NCTC8187

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: DQM64_RS06465
• Protein ID: WP_001030303.1
• Coordinates: 1240948..1241817 (+)
• Length: 290 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: DQM64_RS06460
• Protein ID: WP_000037241.1
• Coordinates: 1240361..1240951 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQM64_RS06460	1240361..1240951	+	591	WP_000037241.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
DQM64_RS06465	1240948..1241817	+	870	WP_001030303.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
DQM64_RS06470	1241878..1244679	-	2802	WP_000656702.1	CHAP domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-257)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 290 a.a.
• Molecular weight: 33445.33 Da
• Isoelectric Point: 6.4928

>T292474 WP_001030303.1 NZ_LS483387:1240948-1241817 [Streptococcus agalactiae]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSEE
TVKQQLKEILADSEEGISFVIQSITTIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKKDIDFNQLKNACQRTFSYRETELDFEKIIELLERFKSDP
TQNQQWQNYSKKYSYTKGISLANVLDEMISLITLLFLLTLIKTFNCPTR

Nucleotide

• Length: 870 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23133.70 Da
• Isoelectric Point: 8.3504

>AT292474 WP_000037241.1 NZ_LS483387:1240361-1240951 [Streptococcus agalactiae]
MSKKEILLDFIEKNNGIVTNKDCKALGIPTIYLTRLEKEGIIFRVEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTVPRGYRFNTPPANLNIHFVSKEYSELGMTTVRTPMGNNVRVYDFERIICDFVIHREKIDSELFVKT
LQSYGNYPKKNLAKLYEYATKMNTLEKVKQTLEVLI

Nucleotide

• Length: 591 bp