292473

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 242635..243247 Replicon chromosome
Accession NZ_LS483387
Organism Streptococcus agalactiae strain NCTC8187

Toxin (Protein)


Gene name parE Uniprot ID Q8E1X3
Locus tag DQM64_RS01420 Protein ID WP_000384858.1
Coordinates 242635..242970 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E1X2
Locus tag DQM64_RS01425 Protein ID WP_000255538.1
Coordinates 242960..243247 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM64_RS01390 237833..238474 + 642 WP_000591144.1 hypothetical protein -
DQM64_RS01400 238774..239649 + 876 WP_000421240.1 hypothetical protein -
DQM64_RS01405 239685..240119 + 435 WP_001220479.1 hypothetical protein -
DQM64_RS01410 240436..241692 + 1257 WP_000122836.1 plasmid recombination protein -
DQM64_RS01415 241860..242330 + 471 WP_000130119.1 hypothetical protein -
DQM64_RS01420 242635..242970 - 336 WP_000384858.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQM64_RS01425 242960..243247 - 288 WP_000255538.1 hypothetical protein Antitoxin
DQM64_RS01430 243754..244044 + 291 WP_000078283.1 WXG100 family type VII secretion target -
DQM64_RS01435 244146..244553 + 408 WP_000749954.1 hypothetical protein -
DQM64_RS01440 244553..245113 + 561 WP_001865562.1 hypothetical protein -
DQM64_RS01445 245086..245766 + 681 WP_001865565.1 hypothetical protein -
DQM64_RS01450 245751..246137 + 387 WP_000259069.1 hypothetical protein -
DQM64_RS01455 246171..246452 + 282 WP_000052406.1 hypothetical protein -
DQM64_RS01475 247295..248155 + 861 WP_000477654.1 Rgg/GadR/MutR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 234663..243521 8858


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13264.04 Da        Isoelectric Point: 5.2388

>T292473 WP_000384858.1 NZ_LS483387:c242970-242635 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10921.47 Da        Isoelectric Point: 4.7271

>AT292473 WP_000255538.1 NZ_LS483387:c243247-242960 [Streptococcus agalactiae]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1EF10

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1EFF9

References