Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1596930..1597542 Replicon chromosome
Accession NZ_LS483382
Organism Streptococcus pyogenes strain NCTC13738

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DQM89_RS08290 Protein ID WP_014635711.1
Coordinates 1597207..1597542 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQM89_RS08285 Protein ID WP_002988079.1
Coordinates 1596930..1597217 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM89_RS08260 1592118..1593101 - 984 WP_076634369.1 tagatose-bisphosphate aldolase -
DQM89_RS08265 1593105..1594034 - 930 WP_076634370.1 tagatose-6-phosphate kinase -
DQM89_RS08270 1594084..1594599 - 516 WP_014407849.1 galactose-6-phosphate isomerase subunit LacB -
DQM89_RS08275 1594634..1595062 - 429 WP_014635709.1 galactose-6-phosphate isomerase subunit LacA -
DQM89_RS08280 1595507..1596280 + 774 WP_023605292.1 DeoR/GlpR family DNA-binding transcription regulator -
DQM89_RS08285 1596930..1597217 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQM89_RS08290 1597207..1597542 + 336 WP_014635711.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQM89_RS09630 1597694..1598116 + 423 Protein_1526 integrase -
DQM89_RS09635 1598512..1598613 + 102 WP_186786566.1 hypothetical protein -
DQM89_RS08305 1598782..1599174 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQM89_RS08310 1599195..1599641 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQM89_RS08315 1599859..1600065 - 207 WP_076634371.1 helix-turn-helix transcriptional regulator -
DQM89_RS08320 1600062..1600760 - 699 WP_168643110.1 hypothetical protein -
DQM89_RS08325 1600896..1601756 - 861 WP_076634373.1 DegV family protein -
DQM89_RS08330 1601853..1602371 - 519 WP_076634374.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13173.94 Da        Isoelectric Point: 5.6809

>T292469 WP_014635711.1 NZ_LS483382:1597207-1597542 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292469 WP_002988079.1 NZ_LS483382:1596930-1597217 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References