Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1234696..1235181 Replicon chromosome
Accession NZ_LS483381
Organism Streptococcus sobrinus strain NCTC10921

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DQM69_RS06020 Protein ID WP_002962001.1
Coordinates 1234696..1234959 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A380JHJ3
Locus tag DQM69_RS06025 Protein ID WP_002997994.1
Coordinates 1234960..1235181 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM69_RS06005 1232272..1232730 - 459 WP_109982636.1 type II toxin-antitoxin system HicB family antitoxin -
DQM69_RS06010 1232833..1233336 - 504 Protein_1123 DUF4411 family protein -
DQM69_RS06015 1233333..1234445 - 1113 WP_002997951.1 ImmA/IrrE family metallo-endopeptidase -
DQM69_RS06020 1234696..1234959 - 264 WP_002962001.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQM69_RS06025 1234960..1235181 - 222 WP_002997994.1 hypothetical protein Antitoxin
DQM69_RS06030 1235304..1238300 - 2997 Protein_1127 type I restriction endonuclease subunit R -
DQM69_RS06035 1238477..1239418 + 942 WP_109982637.1 bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA -
DQM69_RS06040 1239393..1239590 - 198 WP_002962009.1 DUF3272 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1220014..1235205 15191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10517.09 Da        Isoelectric Point: 10.2271

>T292468 WP_002962001.1 NZ_LS483381:c1234959-1234696 [Streptococcus sobrinus]
MYQVRYSKKAQKQIKKLDKSVQRFLFSWIDKHIDGSDNPRQFGKGLSGNHAREWRYRIGDYRLICDIEDDKLIILALEFG
HRRDIYK

Download         Length: 264 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8564.57 Da        Isoelectric Point: 4.4805

>AT292468 WP_002997994.1 NZ_LS483381:c1235181-1234960 [Streptococcus sobrinus]
MSTVTVRLNKDEEDFFKTYAQITGVSLSTLFKKSLEKAIEDEYDLKLYQEAYRAYQEDPETLSHADFKKELGF

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A380JHJ3

References