292467

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 804502..805073 Replicon chromosome
Accession NZ_LS483381
Organism Streptococcus sobrinus strain NCTC10921

Toxin (Protein)


Gene name mazF Uniprot ID U2J9M5
Locus tag DQM69_RS03965 Protein ID WP_021673296.1
Coordinates 804502..804834 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID U2KH30
Locus tag DQM69_RS03970 Protein ID WP_002959726.1
Coordinates 804828..805073 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM69_RS03950 799977..801590 + 1614 WP_109982536.1 alpha-glucosidase -
DQM69_RS03955 802139..802648 + 510 WP_019779284.1 DinB family protein -
DQM69_RS03960 802669..804018 + 1350 WP_109982537.1 replication-associated recombination protein A -
DQM69_RS03965 804502..804834 - 333 WP_021673296.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DQM69_RS03970 804828..805073 - 246 WP_002959726.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DQM69_RS03975 805224..805988 - 765 WP_019769317.1 DeoR/GlpR family DNA-binding transcription regulator -
DQM69_RS03980 806248..806676 + 429 WP_002959730.1 galactose-6-phosphate isomerase subunit LacA -
DQM69_RS03985 806704..807219 + 516 WP_002959732.1 galactose-6-phosphate isomerase subunit LacB -
DQM69_RS03990 807359..808339 + 981 WP_019795477.1 tagatose-bisphosphate aldolase -
DQM69_RS03995 808617..809450 + 834 WP_109982538.1 PRD domain-containing protein -
DQM69_RS04000 809487..809801 + 315 WP_002959739.1 PTS lactose/cellobiose transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12602.63 Da        Isoelectric Point: 9.3092

>T292467 WP_021673296.1 NZ_LS483381:c804834-804502 [Streptococcus sobrinus]
MVEIKQGTIIKINLDPKEGHEQRGYRPYVCLSHSVVQNYSNIAIFAPISNTKRDYPFYVPLEGTKSTGKVLLDQPVTIDF
RARKYKFVEDIADSLLIELLSRVKVIFEKG

Download         Length: 333 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9462.91 Da        Isoelectric Point: 4.8146

>AT292467 WP_002959726.1 NZ_LS483381:c805073-804828 [Streptococcus sobrinus]
MPLTVNKWGNSIAIRLPKQLVQELKLQKDDILDYKISNNKLILEKKSEIPELTVEDLFKDYKGEPVDTTPFIFESKGNEQ
W

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2J9M5

Antitoxin

Source ID Structure
AlphaFold DB U2KH30

References