Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezA/zeta-couple_hipB
Location 784944..785656 Replicon chromosome
Accession NZ_LS483381
Organism Streptococcus sobrinus strain NCTC10921

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag DQM69_RS03880 Protein ID WP_019769405.1
Coordinates 785420..785656 (+) Length 79 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag DQM69_RS03875 Protein ID WP_019769406.1
Coordinates 784944..785420 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM69_RS03855 780789..782615 + 1827 WP_109982530.1 beta-glucoside-specific PTS transporter subunit IIABC -
DQM69_RS03860 782626..782787 + 162 WP_109982531.1 family 1 glycosylhydrolase -
DQM69_RS03865 782866..783855 - 990 WP_111687995.1 IS30 family transposase -
DQM69_RS03870 784381..784827 + 447 WP_109982533.1 SWIM zinc finger domain-containing protein -
DQM69_RS03875 784944..785420 + 477 WP_019769406.1 helix-turn-helix domain-containing protein Antitoxin
DQM69_RS03880 785420..785656 + 237 WP_019769405.1 zeta toxin family protein Toxin
DQM69_RS03885 785678..785812 + 135 WP_002959687.1 zeta toxin family protein -
DQM69_RS03890 785850..786197 + 348 WP_109833614.1 zeta toxin family protein -
DQM69_RS03895 786713..788956 + 2244 WP_002959690.1 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 782866..783855 989


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-77)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 79 a.a.        Molecular weight: 8497.79 Da        Isoelectric Point: 10.3607

>T292466 WP_019769405.1 NZ_LS483381:785420-785656 [Streptococcus sobrinus]
MIVAKFTEAELNRALIRNSRALIRGKKPSEHPTAILLGGQSGAGKTTIHRIKQEAYQGNIIVIDGDSFCPQHPNFSAL

Download         Length: 237 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18036.83 Da        Isoelectric Point: 4.8894

>AT292466 WP_019769406.1 NZ_LS483381:784944-785420 [Streptococcus sobrinus]
MIGENIKALRKKRELTQPEFAKIIGISRNSLSRYENGTSSVSTDLLDLICKKFNVSYIDIVGKEKLLRPIEDYQLTLKIE
LAKERGVNLLARLYAFQDEQGIAVDDEANPWVLMGDDLADLVHTKIYLVNTFEEFERYMGYLDGIERMLSMAKQGVAV

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References