Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1517648..1518260 Replicon chromosome
Accession NZ_LS483379
Organism Streptococcus pyogenes strain NCTC10874

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DQM61_RS07740 Protein ID WP_002994716.1
Coordinates 1517925..1518260 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQM61_RS07735 Protein ID WP_002988079.1
Coordinates 1517648..1517935 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM61_RS07710 1512839..1513822 - 984 WP_014407847.1 tagatose-bisphosphate aldolase -
DQM61_RS07715 1513826..1514755 - 930 WP_023609980.1 tagatose-6-phosphate kinase -
DQM61_RS07720 1514801..1515316 - 516 WP_014407849.1 galactose-6-phosphate isomerase subunit LacB -
DQM61_RS07725 1515351..1515779 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
DQM61_RS07730 1516225..1516998 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
DQM61_RS07735 1517648..1517935 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQM61_RS07740 1517925..1518260 + 336 WP_002994716.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQM61_RS09050 1518412..1518882 + 471 WP_021733374.1 site-specific integrase -
DQM61_RS09055 1518845..1519393 + 549 WP_136115776.1 site-specific integrase -
DQM61_RS07750 1519513..1519905 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQM61_RS07755 1519926..1520372 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQM61_RS07760 1520590..1520796 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQM61_RS07765 1520793..1521299 - 507 WP_002988070.1 hypothetical protein -
DQM61_RS07770 1521435..1522295 - 861 WP_002982687.1 DegV family protein -
DQM61_RS07775 1522392..1522910 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13154.89 Da        Isoelectric Point: 5.6157

>T292463 WP_002994716.1 NZ_LS483379:1517925-1518260 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292463 WP_002988079.1 NZ_LS483379:1517648-1517935 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References