Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 826087..826658 Replicon chromosome
Accession NZ_LS483378
Organism Streptococcus sobrinus strain NCTC12279

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DQM97_RS04060 Protein ID WP_002959724.1
Coordinates 826087..826419 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID U2KH30
Locus tag DQM97_RS04065 Protein ID WP_002959726.1
Coordinates 826413..826658 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM97_RS04045 821561..823174 + 1614 WP_028798515.1 alpha-glucosidase -
DQM97_RS04050 823724..824233 + 510 WP_002959718.1 DinB family protein -
DQM97_RS04055 824254..825603 + 1350 WP_028798514.1 replication-associated recombination protein A -
DQM97_RS04060 826087..826419 - 333 WP_002959724.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DQM97_RS04065 826413..826658 - 246 WP_002959726.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DQM97_RS04070 826809..827573 - 765 WP_019769317.1 DeoR/GlpR family DNA-binding transcription regulator -
DQM97_RS04075 827833..828261 + 429 WP_002959730.1 galactose-6-phosphate isomerase subunit LacA -
DQM97_RS04080 828289..828804 + 516 WP_002959732.1 galactose-6-phosphate isomerase subunit LacB -
DQM97_RS04085 828944..829924 + 981 WP_002959735.1 tagatose-bisphosphate aldolase -
DQM97_RS04090 830202..831035 + 834 WP_002959738.1 PRD domain-containing protein -
DQM97_RS04095 831072..831386 + 315 WP_002959739.1 PTS lactose/cellobiose transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12689.79 Da        Isoelectric Point: 9.5954

>T292460 WP_002959724.1 NZ_LS483378:c826419-826087 [Streptococcus sobrinus]
MVEIKQGTIIKINLDPKEGHEQRGYRPYVCLSHSVVQNYSNIAIFAPISNTKRDYPFYVPLKGTKSTGKVLLDQLVTIDF
RARKYKFVEDIADSLLIELLSRVKVIFEKE

Download         Length: 333 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9462.91 Da        Isoelectric Point: 4.8146

>AT292460 WP_002959726.1 NZ_LS483378:c826658-826413 [Streptococcus sobrinus]
MPLTVNKWGNSIAIRLPKQLVQELKLQKDDILDYKISNNKLILEKKSEIPELTVEDLFKDYKGEPVDTTPFIFESKGNEQ
W

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U2KH30

References