Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezA/zeta-couple_hipB
Location 805069..805781 Replicon chromosome
Accession NZ_LS483378
Organism Streptococcus sobrinus strain NCTC12279

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag DQM97_RS03975 Protein ID WP_002959684.1
Coordinates 805545..805781 (+) Length 79 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag DQM97_RS03970 Protein ID WP_002959682.1
Coordinates 805069..805545 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM97_RS03950 800914..802740 + 1827 WP_028798479.1 beta-glucoside-specific PTS transporter subunit IIABC -
DQM97_RS03955 802751..802912 + 162 WP_002963117.1 family 1 glycosylhydrolase -
DQM97_RS03960 802991..803980 - 990 WP_111679792.1 IS30 family transposase -
DQM97_RS03965 804506..804952 + 447 WP_002959681.1 SWIM zinc finger domain-containing protein -
DQM97_RS03970 805069..805545 + 477 WP_002959682.1 helix-turn-helix domain-containing protein Antitoxin
DQM97_RS03975 805545..805781 + 237 WP_002959684.1 zeta toxin family protein Toxin
DQM97_RS03980 805803..805937 + 135 WP_002959687.1 zeta toxin family protein -
DQM97_RS03985 805975..806322 + 348 Protein_728 zeta toxin family protein -
DQM97_RS03990 806837..809080 + 2244 WP_002959690.1 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 802991..803980 989


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-77)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 79 a.a.        Molecular weight: 8485.73 Da        Isoelectric Point: 10.3607

>T292459 WP_002959684.1 NZ_LS483378:805545-805781 [Streptococcus sobrinus]
MIVAKFTEAELNRALTRNSRALIRGKKPSEHPTAILLGGQSGAGKTTIHRIKQEAYQGNIIVIDGDSFCPQHPNFSAL

Download         Length: 237 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18052.88 Da        Isoelectric Point: 4.8894

>AT292459 WP_002959682.1 NZ_LS483378:805069-805545 [Streptococcus sobrinus]
MIGENIKALRKKRELTQPEFAKIIGISRNSLSRYENGTSSVSTDLLDLICKKFNVSYIDIVGKEKLLRPIEDYQLTLKIE
LAKERGVNLLARLYAFQDEQGIAVDDEANLWVLMGDDLADLVHTKIYLVNTFEEFERYMGYLDGIERMLSMAKQGVAV

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References