Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH
Location 62240..62732 Replicon chromosome
Accession NZ_LS483378
Organism Streptococcus sobrinus strain NCTC12279

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DQM97_RS00365 Protein ID WP_002959575.1
Coordinates 62466..62732 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag DQM97_RS00360 Protein ID WP_002959577.1
Coordinates 62240..62473 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM97_RS00335 57416..57613 + 198 WP_002959584.1 hypothetical protein -
DQM97_RS00340 57610..59157 + 1548 WP_002959583.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
DQM97_RS00345 59361..59900 - 540 WP_002959581.1 TetR/AcrR family transcriptional regulator -
DQM97_RS00350 60053..60574 + 522 WP_002959580.1 HXXEE domain-containing protein -
DQM97_RS00355 60900..62111 + 1212 WP_028798497.1 LysM peptidoglycan-binding domain-containing protein -
DQM97_RS00360 62240..62473 + 234 WP_002959577.1 hypothetical protein Antitoxin
DQM97_RS00365 62466..62732 + 267 WP_002959575.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQM97_RS00370 62800..63957 - 1158 WP_019776570.1 AIPR family protein -
DQM97_RS00375 64079..64354 + 276 WP_002959570.1 helix-turn-helix domain-containing protein -
DQM97_RS00380 64520..65779 + 1260 WP_002959569.1 phosphoribosylamine--glycine ligase -
DQM97_RS00385 65776..66219 + 444 WP_002959567.1 DUF523 domain-containing protein -
DQM97_RS00390 66343..67554 + 1212 WP_002959564.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10419.20 Da        Isoelectric Point: 10.8196

>T292457 WP_002959575.1 NZ_LS483378:62466-62732 [Streptococcus sobrinus]
MYRLVLSKRFIKQIKKFDKYTVNSILVWLEKNIDGSDNPRQHGKALVGNLKGLWRYRIGNYRVVCRIQDEELVVVAVSGG
HRRDIYKR

Download         Length: 267 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8552.48 Da        Isoelectric Point: 4.0776

>AT292457 WP_002959577.1 NZ_LS483378:62240-62473 [Streptococcus sobrinus]
MAVVSLRLNQEEESFFKNYADFTGKSLSSLFKEALAQEIEDELDYKLGVEGVRAFEADGGQGYSIAEARKELGLENV

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References