Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 123756..125339 Replicon chromosome
Accession NZ_LS483377
Organism Stenotrophomonas maltophilia strain NCTC10258

Toxin (Protein)


Gene name hipA Uniprot ID B2FHA0
Locus tag DQN92_RS00530 Protein ID WP_012478717.1
Coordinates 123756..125078 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag DQN92_RS00535 Protein ID WP_005407534.1
Coordinates 125082..125339 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN92_RS00515 119156..120790 - 1635 WP_005407530.1 TldD/PmbA family protein -
DQN92_RS00520 120821..122452 - 1632 WP_012478715.1 TldD/PmbA family protein -
DQN92_RS00525 123141..123755 + 615 WP_005407532.1 DUF938 domain-containing protein -
DQN92_RS00530 123756..125078 - 1323 WP_012478717.1 type II toxin-antitoxin system HipA family toxin Toxin
DQN92_RS00535 125082..125339 - 258 WP_005407534.1 helix-turn-helix transcriptional regulator Antitoxin
DQN92_RS00540 125501..129187 - 3687 WP_111686729.1 indolepyruvate ferredoxin oxidoreductase family protein -
DQN92_RS00545 129359..129994 + 636 WP_005407536.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-70)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49058.99 Da        Isoelectric Point: 7.0868

>T292454 WP_012478717.1 NZ_LS483377:c125078-123756 [Stenotrophomonas maltophilia]
MGTLQVWMNGVEVALWDDVRNGSSRLSYVSQWISSPQSRPLSLSLPLLPDGESHRGNVVNDYFDNLLPDNVAIRNRIRDR
FATRGSDTFDLLEAIGRDCVGAVQLLPPARPPEDIQQITCEVLDEAGVATILRQVTTGNLPGAPSRDDAFRISIAGAQEK
TGLLLHAGKWCIPTGNTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMHLLSAFDIPVAETQMGRFNDQRALIVERFDRR
LSADRRWWLRLPQEDMCQVFGLPAARKYESDGGPGIVPIMDLLRQSEHPEDRAIFFKTQILFWMLAATDGHAKNFSVHLE
AGGRFRLTPVYDVLSVYPILGRGPNQLDPRNAQLAMAVHGKNRHRKLHLVRRRHWNETARACGVADGAEPWIKTLIAAVE
PAIQQVTRQLPDDFPSNVSEPIFNGLRAAAARLSSMAPEA

Download         Length: 1323 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9584.97 Da        Isoelectric Point: 11.8468

>AT292454 WP_005407534.1 NZ_LS483377:c125339-125082 [Stenotrophomonas maltophilia]
MDRPLHTVRTAQQLAPLMRAFRRQAGLSQAQLAERLGISRQAVGALERDPASASFERLMRIWAVLGLEVSLQQRSPQENT
SSLEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G7P5V7

Antitoxin

Source ID Structure

References