Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sezT-pezT/zeta-couple_hipB |
| Location | 383253..384496 | Replicon | chromosome |
| Accession | NZ_LS483375 | ||
| Organism | Streptococcus gordonii strain NCTC3165 | ||
Toxin (Protein)
| Gene name | sezT | Uniprot ID | - |
| Locus tag | DQM54_RS01875 | Protein ID | WP_111723271.1 |
| Coordinates | 383729..384496 (+) | Length | 256 a.a. |
Antitoxin (Protein)
| Gene name | pezT | Uniprot ID | A0A6I3P6W1 |
| Locus tag | DQM54_RS01870 | Protein ID | WP_046165028.1 |
| Coordinates | 383253..383729 (+) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DQM54_RS01845 | 378910..379521 | - | 612 | WP_000240415.1 | Fic family protein | - |
| DQM54_RS01850 | 379514..379702 | - | 189 | WP_000171300.1 | hypothetical protein | - |
| DQM54_RS01855 | 379850..380350 | + | 501 | WP_045505588.1 | hypothetical protein | - |
| DQM54_RS01860 | 381080..382597 | - | 1518 | WP_046165027.1 | ABC transporter ATP-binding protein/permease | - |
| DQM54_RS01865 | 382581..383103 | - | 523 | Protein_358 | SPASM domain-containing protein | - |
| DQM54_RS01870 | 383253..383729 | + | 477 | WP_046165028.1 | helix-turn-helix domain-containing protein | Antitoxin |
| DQM54_RS01875 | 383729..384496 | + | 768 | WP_111723271.1 | zeta toxin family protein | Toxin |
| DQM54_RS01885 | 384764..385021 | + | 258 | WP_046165030.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| DQM54_RS01890 | 385018..385389 | + | 372 | WP_046165031.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| DQM54_RS01895 | 386078..387034 | + | 957 | WP_061583301.1 | hypothetical protein | - |
| DQM54_RS01900 | 387077..387205 | + | 129 | WP_081325072.1 | conjugal transfer protein TraX | - |
| DQM54_RS01905 | 387358..387561 | - | 204 | WP_008808393.1 | CsbD family protein | - |
| DQM54_RS01910 | 387743..388375 | - | 633 | WP_172455857.1 | DUF421 domain-containing protein | - |
| DQM54_RS01915 | 388372..388824 | - | 453 | WP_111723272.1 | DUF3290 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 368168..390302 | 22134 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 256 a.a. Molecular weight: 29184.16 Da Isoelectric Point: 7.0531
>T292453 WP_111723271.1 NZ_LS483375:383729-384496 [Streptococcus gordonii]
MKLEEFSQDDFERASRRLVRSLTRGKTTSSQPKAILLGGQSGAGKTTIHRIKQREFQGNIIIIDGDSYRSFHPNYLGLQE
KYGKDSVDYTKVFAGQMVEYLVDELSKQGYHLLIEGTLRTTEVPRKTAQLLITKGYQVSLALIATKPELSYLSTLIRYEE
LYAIDSSQARATPKAHHDGIVEHMVDNLRELENDKLFRQIQIYQRDQSCVYDSQVDQISAAEVLQECLFGKWSKVEEEML
KLGQERLREMGGINK
MKLEEFSQDDFERASRRLVRSLTRGKTTSSQPKAILLGGQSGAGKTTIHRIKQREFQGNIIIIDGDSYRSFHPNYLGLQE
KYGKDSVDYTKVFAGQMVEYLVDELSKQGYHLLIEGTLRTTEVPRKTAQLLITKGYQVSLALIATKPELSYLSTLIRYEE
LYAIDSSQARATPKAHHDGIVEHMVDNLRELENDKLFRQIQIYQRDQSCVYDSQVDQISAAEVLQECLFGKWSKVEEEML
KLGQERLREMGGINK
Download Length: 768 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 18054.48 Da Isoelectric Point: 4.3745
>AT292453 WP_046165028.1 NZ_LS483375:383253-383729 [Streptococcus gordonii]
MIGENIKALRKTHDLTQPEFAKIVGISRNSLSRYENGTSSISTELIDRICQKFNVSYIDIVGEEKMLTPVEDYQLTLKIE
VIKERGANILAQLYRFQDEQGIAFDDTSNPWVLMSDDLSDLLNTKIYLVGTFDEVERYNGYLDGIERMLEQATHLVVA
MIGENIKALRKTHDLTQPEFAKIVGISRNSLSRYENGTSSISTELIDRICQKFNVSYIDIVGEEKMLTPVEDYQLTLKIE
VIKERGANILAQLYRFQDEQGIAFDDTSNPWVLMSDDLSDLLNTKIYLVGTFDEVERYNGYLDGIERMLEQATHLVVA
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|