Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 3790161..3790774 Replicon chromosome
Accession NZ_LS483372
Organism Pseudomonas fluorescens strain NCTC10038

Toxin (Protein)


Gene name hicA Uniprot ID A0A172Z267
Locus tag DQO01_RS17290 Protein ID WP_053256594.1
Coordinates 3790161..3790412 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1E4XBZ6
Locus tag DQO01_RS17295 Protein ID WP_053256595.1
Coordinates 3790409..3790774 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQO01_RS17290 3790161..3790412 + 252 WP_053256594.1 type II toxin-antitoxin system HicA family toxin Toxin
DQO01_RS17295 3790409..3790774 + 366 WP_053256595.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DQO01_RS17300 3790757..3791947 - 1191 WP_053256596.1 MFS transporter -
DQO01_RS17305 3792090..3792683 + 594 WP_053256597.1 TetR/AcrR family transcriptional regulator -
DQO01_RS17310 3792667..3794022 - 1356 WP_053256598.1 MATE family efflux transporter -
DQO01_RS17315 3794048..3794620 - 573 WP_053256599.1 DUF2239 family protein -
DQO01_RS17320 3794661..3795644 - 984 WP_053256600.1 ATP-dependent Clp protease ATP-binding subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9485.04 Da        Isoelectric Point: 9.6594

>T292448 WP_053256594.1 NZ_LS483372:3790161-3790412 [Pseudomonas fluorescens]
VSKNEKLLAKLLNEHMAFTWPELVTLLHRLGYTQIEGAGSRVKFDIGDPSAMISLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Download         Length: 252 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13215.09 Da        Isoelectric Point: 6.6270

>AT292448 WP_053256595.1 NZ_LS483372:3790409-3790774 [Pseudomonas fluorescens]
VNNQLKYNGYIGSIEASLEDNCLFGKILFIKALVSYEGKTVAELDAAFREAVDDYLATCHALGQTPEKPCKGSFNVRVGH
DLHLAAALAATRKKVTLNDLTRQALNEFLQHHCAEPLSVLG

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A172Z267

Antitoxin

Source ID Structure
AlphaFold DB A0A1E4XBZ6

References