Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 4793074..4794671 Replicon chromosome
Accession NZ_LS483370
Organism Pseudomonas taetrolens strain NCTC10697

Toxin (Protein)


Gene name hipA Uniprot ID A0A0J6GTI8
Locus tag DQN55_RS22005 Protein ID WP_048381606.1
Coordinates 4793346..4794671 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag DQN55_RS22000 Protein ID WP_048381608.1
Coordinates 4793074..4793349 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN55_RS21975 4788447..4789547 + 1101 WP_048381614.1 polyamine ABC transporter substrate-binding protein -
DQN55_RS21980 4789601..4791148 - 1548 WP_048381613.1 PLP-dependent aminotransferase family protein -
DQN55_RS21985 4791238..4791867 + 630 WP_048381611.1 FMN-binding negative transcriptional regulator -
DQN55_RS21990 4791872..4792324 + 453 WP_048381610.1 GNAT family N-acetyltransferase -
DQN55_RS21995 4792338..4793018 + 681 WP_048381609.1 GNAT family N-acetyltransferase -
DQN55_RS22000 4793074..4793349 - 276 WP_048381608.1 helix-turn-helix domain-containing protein Antitoxin
DQN55_RS22005 4793346..4794671 - 1326 WP_048381606.1 HipA domain-containing protein Toxin
DQN55_RS22010 4794894..4796702 - 1809 WP_048381605.1 sodium-extruding oxaloacetate decarboxylase subunit alpha -
DQN55_RS22015 4796714..4798129 - 1416 WP_048381600.1 acetyl-CoA carboxylase biotin carboxylase subunit -
DQN55_RS22020 4798320..4799282 + 963 WP_048381599.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-369)

Antitoxin

Cro/C1-type helix-turn-helix domain

(27-80)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 49001.72 Da        Isoelectric Point: 5.0869

>T292447 WP_048381606.1 NZ_LS483370:c4794671-4793346 [Pseudomonas taetrolens]
MFQLTLQLYSAGQWLDAMTLAFPEPEKGLDGPCRFGYKQDYLLDNLGAIDSPFAASVSACVPLEWDARHTKQAPAFLHDI
APAGAAKKVLIKQIGREKPEHLSDDLFLLGRSTPAPIGHLRIKESFEQLDQRQAMGFSREDVIVRDNSFLEYAHEQGAAI
GGATGAGGEAPKLLMAEGADGLLYPDATLADAQVKQHWFIKFARNQAFERDQVILRSEFLYYQALQALGIETVPAQGLAL
EEGRKPSLWMQRFDRHIEAQGVQRYAVESIYSLAQVTEPGSTMTHLEVVELLATLWTQAGQQAQIPDLVAEYLRRDLLNK
ILGNSDNHGRNTAIIRGSDSFRLAPIYDLAPMVMDDEGITRTTKWPLAIERAGAVDWRAACDSLRGVIDPQLAFDRLRHD
AQQLLALPDLLSASGLPDVTMNHPQIALRNLDQRLQEWGLK

Download         Length: 1326 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10401.16 Da        Isoelectric Point: 10.6965

>AT292447 WP_048381608.1 NZ_LS483370:c4793349-4793074 [Pseudomonas taetrolens]
MTLSIDVRQAKIQSIEDDLAQGKITLGEAVKRFRVDVTQLQQTQYARMCKISVRTLIQIEHDEGNPTLKSLNAVFKPFGL
QMGVVRRPRKF

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J6GTI8

Antitoxin

Source ID Structure

References