Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 272289..272901 Replicon chromosome
Accession NZ_LS483367
Organism Streptococcus dysgalactiae subsp. equisimilis strain NCTC5371

Toxin (Protein)


Gene name parE Uniprot ID Q8E7D3
Locus tag DQM52_RS01520 Protein ID WP_000384859.1
Coordinates 272289..272624 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID G5KDE1
Locus tag DQM52_RS01525 Protein ID WP_006738697.1
Coordinates 272614..272901 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM52_RS01495 268013..268447 + 435 WP_001220480.1 hypothetical protein -
DQM52_RS01500 268764..270020 + 1257 WP_111681514.1 plasmid recombination protein -
DQM52_RS01505 270188..270676 + 489 WP_111681515.1 hypothetical protein -
DQM52_RS01510 270722..271855 + 1134 WP_022554244.1 ISAs1-like element IS1548 family transposase -
DQM52_RS01520 272289..272624 - 336 WP_000384859.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQM52_RS01525 272614..272901 - 288 WP_006738697.1 hypothetical protein Antitoxin
DQM52_RS01530 273112..273195 + 84 Protein_248 30S ribosomal protein S9 -
DQM52_RS01535 273306..274526 - 1221 WP_111681516.1 tyrosine-type recombinase/integrase -
DQM52_RS01540 274595..274855 - 261 WP_111681517.1 helix-turn-helix domain-containing protein -
DQM52_RS01545 274833..275432 - 600 WP_111681518.1 replication protein -
DQM52_RS01550 275623..276234 - 612 WP_070811395.1 hypothetical protein -
DQM52_RS01555 276234..277310 - 1077 WP_111681949.1 cell division protein FtsK -
DQM52_RS01560 277320..277597 - 278 Protein_254 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 270722..271855 1133


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13296.98 Da        Isoelectric Point: 4.6565

>T292444 WP_000384859.1 NZ_LS483367:c272624-272289 [Streptococcus dysgalactiae subsp. equisimilis]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10878.45 Da        Isoelectric Point: 4.7271

>AT292444 WP_006738697.1 NZ_LS483367:c272901-272614 [Streptococcus dysgalactiae subsp. equisimilis]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G5KDE1

References